The cholinergic anti-inflammatory pathway: An innovative treatment strategy for neurological diseases
B Han, X Li, J Hao - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Acetylcholine (ACh), as a classical neurotransmitter, regulates the neuronal network in
response to internal and external stimuli. In recent decades, the biology of ACh has been …
response to internal and external stimuli. In recent decades, the biology of ACh has been …
[HTML][HTML] Cholinergic system and its therapeutic importance in inflammation and autoimmunity
N Halder, G Lal - Frontiers in immunology, 2021 - frontiersin.org
Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …
body that maintains physiology and homeostasis. The cholinergic system plays a significant …
[HTML][HTML] Cholinergic modulation of the immune system in neuroinflammatory diseases
M Reale, E Costantini - Diseases, 2021 - mdpi.com
Frequent diseases of the CNS, such as Alzheimer's disease, Parkinson's disease, multiple
sclerosis, and psychiatric disorders (eg, schizophrenia), elicit a neuroinflammatory response …
sclerosis, and psychiatric disorders (eg, schizophrenia), elicit a neuroinflammatory response …
Cholinergic signaling controls immune functions and promotes homeostasis
I Wessler, CJ Kirkpatrick - International Immunopharmacology, 2020 - Elsevier
Acetylcholine (ACh) was created by nature as one of the first signaling molecules,
expressed already in procaryotes. Based on the positively charged nitrogen, ACh could …
expressed already in procaryotes. Based on the positively charged nitrogen, ACh could …
Cholinergic system and neuroinflammation: implication in multiple sclerosis
M Di Bari, G Di Pinto, M Reale… - … System Agents in …, 2017 - ingentaconnect.com
Background: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of
the central nervous system (CNS) characterized by leucocytes infiltration, demyelination …
the central nervous system (CNS) characterized by leucocytes infiltration, demyelination …
[HTML][HTML] The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
This review outlines the mechanisms underlying the interaction between the nervous and
immune systems of the host in response to an immune challenge. The main focus is the …
immune systems of the host in response to an immune challenge. The main focus is the …
The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans
I Wessler, CJ Kirkpatrick… - Clinical and Experimental …, 1999 - Wiley Online Library
1. Acetylcholine (ACh) represents one of the most exemplary neurotransmitters. In addition
to its presence in neuronal tissue, there is increasing experimental evidence that ACh is …
to its presence in neuronal tissue, there is increasing experimental evidence that ACh is …
[HTML][HTML] Regulated extracellular choline acetyltransferase activity—the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory …
S Vijayaraghavan, A Karami, S Aeinehband… - PloS one, 2013 - journals.plos.org
Acetylcholine (ACh), the classical neurotransmitter, also affects a variety of nonexcitable
cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system …
cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system …
[HTML][HTML] The cholinergic pathways in inflammation: a potential pharmacotherapeutic target for COPD
M Yamada, M Ichinose - Frontiers in pharmacology, 2018 - frontiersin.org
In COPD, the activity of the cholinergic system is increased, which is one of the reasons for
the airflow limitation caused by the contraction of airway smooth muscles. Therefore …
the airflow limitation caused by the contraction of airway smooth muscles. Therefore …
The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation
EM Nicolussi, S Huck, H Lassmann, M Bradl - Neurobiology of disease, 2009 - Elsevier
Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRα7) by nicotine or
acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural …
acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural …