The cholinergic anti-inflammatory pathway: An innovative treatment strategy for neurological diseases

B Han, X Li, J Hao - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Acetylcholine (ACh), as a classical neurotransmitter, regulates the neuronal network in
response to internal and external stimuli. In recent decades, the biology of ACh has been …

[HTML][HTML] Cholinergic system and its therapeutic importance in inflammation and autoimmunity

N Halder, G Lal - Frontiers in immunology, 2021 - frontiersin.org
Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

[HTML][HTML] Cholinergic modulation of the immune system in neuroinflammatory diseases

M Reale, E Costantini - Diseases, 2021 - mdpi.com
Frequent diseases of the CNS, such as Alzheimer's disease, Parkinson's disease, multiple
sclerosis, and psychiatric disorders (eg, schizophrenia), elicit a neuroinflammatory response …

Cholinergic signaling controls immune functions and promotes homeostasis

I Wessler, CJ Kirkpatrick - International Immunopharmacology, 2020 - Elsevier
Acetylcholine (ACh) was created by nature as one of the first signaling molecules,
expressed already in procaryotes. Based on the positively charged nitrogen, ACh could …

Cholinergic system and neuroinflammation: implication in multiple sclerosis

M Di Bari, G Di Pinto, M Reale… - … System Agents in …, 2017 - ingentaconnect.com
Background: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of
the central nervous system (CNS) characterized by leucocytes infiltration, demyelination …

[HTML][HTML] The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation

VA Pavlov, H Wang, CJ Czura, SG Friedman… - Molecular …, 2003 - Springer
This review outlines the mechanisms underlying the interaction between the nervous and
immune systems of the host in response to an immune challenge. The main focus is the …

The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans

I Wessler, CJ Kirkpatrick… - Clinical and Experimental …, 1999 - Wiley Online Library
1. Acetylcholine (ACh) represents one of the most exemplary neurotransmitters. In addition
to its presence in neuronal tissue, there is increasing experimental evidence that ACh is …

[HTML][HTML] Regulated extracellular choline acetyltransferase activity—the plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory …

S Vijayaraghavan, A Karami, S Aeinehband… - PloS one, 2013 - journals.plos.org
Acetylcholine (ACh), the classical neurotransmitter, also affects a variety of nonexcitable
cells, such as endothelia, microglia, astrocytes and lymphocytes in both the nervous system …

[HTML][HTML] The cholinergic pathways in inflammation: a potential pharmacotherapeutic target for COPD

M Yamada, M Ichinose - Frontiers in pharmacology, 2018 - frontiersin.org
In COPD, the activity of the cholinergic system is increased, which is one of the reasons for
the airflow limitation caused by the contraction of airway smooth muscles. Therefore …

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation

EM Nicolussi, S Huck, H Lassmann, M Bradl - Neurobiology of disease, 2009 - Elsevier
Stimulation of the nicotinic alpha7 acetylcholine receptor (nAChRα7) by nicotine or
acetylcholine initiates the cholinergic anti-inflammatory pathway, a mechanism for neural …