Transplatin is an inactive platinum drug; however, a number of analogues, such as trans-EE
and trans-PtTz, demonstrate promising antitumor activity in vitro and in vivo. Although the …

Cisplatin is an anticancer drug widely used in clinics; it induces the apoptosis of cancer cells
by targeting DNA. However, its interaction with proteins has been found to be crucial in …

Increasing evidence indicates that sulfur-containing molecules can play important roles in
the activity of platinum anticancer drugs. Although nuclear DNA is retained to be the ultimate …

X-ray crystallographic and biochemical investigation of the reaction of cisplatin and
oxaliplatin with nucleosome core particle and naked DNA reveals that histone octamer …

The binding of the antitumor drug cis-dichlorodiammineplatinum (II) and its inactive trans
isomer with the nucleosome core particle has been investigated. Kinetic studies show that …

Although genomic DNA is the primary target of anticancer platinum-based drugs,
interactions with proteins also play a significant role in their overall activity. In this study …

The mechanism of action of clinically used Pt-based drugs is through the formation of stable
DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or two …

Thioether binding mediates monofunctional platinum antitumor reagents to trans
configuration in DNA interactions - Chemical Communications (RSC Publishing) DOI:10.1039/C0CC01408G …

Simultaneous exposure of transplatin to polypeptides and DNA was mimicked by using a
model peptide–oligonucleotide conjugate. Initially formed methionine–guanine chelates …

Platinum anticancer compounds are currently in widespread use for the treatment of
genitourinary and other tumors. In order to understand the mechanism of action of this …