DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand
R Prokop, J Kasparkova, O Novakova, V Marini… - Biochemical …, 2004 - Elsevier
The global modification of mammalian and plasmid DNAs by novel platinum compounds,
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …
trans-[PtCl2 (NH3)(Am)], where Am= 2-methylbutylamine or sec-butylamine was …
Kinetic Analysis of the Stepwise Platination of Single‐ and Double‐Stranded GG Oligonucleotides with Cisplatin and cis‐[PtCl(H2O)(NH3)2]+
PJ Sadler, KJ Barnham… - … –A European Journal, 1996 - Wiley Online Library
We report the first direct comparison of the kinetics of platination of defined single‐and
double‐stranded DNA with the anticancer drug cisplatin. The courses of the reactions of the …
double‐stranded DNA with the anticancer drug cisplatin. The courses of the reactions of the …
Identification by NMR Spectroscopy of the Two Stereoisomers of the Platinum Complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-Aminohexahydroazepine) Bound to a DNA …
CI Diakos, BA Messerle… - Inorganic …, 2009 - ACS Publications
The enantiomers of the asymmetric, chiral platinum (II) complex [PtCl2 (S-ahaz)](S-ahaz= 3
(S)-aminohexahydroazepine) each form two stereoisomers on binding to GpG sequences of …
(S)-aminohexahydroazepine) each form two stereoisomers on binding to GpG sequences of …
Interaction of histone H1 with cis-platinum modified DNA
EG Paneva, NC Spassovska… - … für Naturforschung C, 1998 - degruyter.com
Abstract Cis-diamminedichloroplatinum (II)(cis-DDP) is known as an effective anticancer
drug. Its therapeutic effect is supposed to be a consequence of the covalent binding to DNA …
drug. Its therapeutic effect is supposed to be a consequence of the covalent binding to DNA …
Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes
Y Qu, A Harris, A Hegmans, A Petz… - Journal of inorganic …, 2004 - Elsevier
Polynuclear platinum compounds demonstrate many novel phenomena in their interactions
with DNA and proteins as well as novel anti-cancer activities. Previous studies indicated that …
with DNA and proteins as well as novel anti-cancer activities. Previous studies indicated that …
Steric control of stereoselective interactions between the platinum (II) complex [PtCl 2 (1, 4-diazacycloheptane)] and DNA: comparison with cis-[PtCl 2 (NH 3) 2] and …
TW Hambley, EC Ling, VP Munk, MS Davies - JBIC Journal of Biological …, 2001 - Springer
The rate and extent of binding of [PtCl 2 (hpip)](hpip= homopiperazine= 1, 4-
diazacycloheptane) and cis-[PtCl 2 (NH 3) 2] to calf thymus DNA was measured using …
diazacycloheptane) and cis-[PtCl 2 (NH 3) 2] to calf thymus DNA was measured using …
Chemical versatility of transplatin monofunctional adducts within multiple site-specifically platinated DNA
E Bernal-Méndez, M Boudvillain… - Biochemistry, 1997 - ACS Publications
The first step of the reaction between DNA and the antitumor drug cisplatin or its clinically
inactive isomer transplatin yields monofunctional adducts. Most of the cisplatin …
inactive isomer transplatin yields monofunctional adducts. Most of the cisplatin …
Trans-platinum(II) complexes with cyclohexylamine as expectator ligand induce necrosis in tumour cells by inhibiting DNA synthesis and RNA transcription
V Cepero, B Garcia-Serrelde, V Moneo… - Clinical and …, 2007 - Springer
Background Enhanced removal of cisplatin-DNA adducts has been reported as one of main
causesof cell resistance to cisplatin. This particular resistance mechanism may be …
causesof cell resistance to cisplatin. This particular resistance mechanism may be …
Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine
ME Oehlsen, A Hegmans, Y Qu, N Farrell - JBIC Journal of Biological …, 2005 - Springer
In this study, the reactions of N-acetyl-L-methionine (AcMet) with [{trans-PtCl (NH 3) 2} 2-μ-H
2 N (CH 2) 6 NH 2](NO 3) 2 (BBR3005: 1, 1/t, t 1) and its cis analog [{cis-PtCl (NH 3) 2} 2-μ …
2 N (CH 2) 6 NH 2](NO 3) 2 (BBR3005: 1, 1/t, t 1) and its cis analog [{cis-PtCl (NH 3) 2} 2-μ …
Platinum—Oligonucleotide Structures and Their Relevance to Platinum—DNA Interaction
JC CHOTTARD, JP GIRAULT, ER GUITTET… - 1983 - ACS Publications
The stoichiometric reactions of nine oxy and deoxy guanine and/or cytosine containing
dinucleotides with cis-[Pt (NH3) 2 (H2O) 2](NO3) 2 (10-5-5 x 10-4 M) in water give …
dinucleotides with cis-[Pt (NH3) 2 (H2O) 2](NO3) 2 (10-5-5 x 10-4 M) in water give …