Dinuclear Platinum Complexes Form a Novel Intrastrand Adduct with d(GpG), an anti−syn Conformation of the Macrochelate As Observed by NMR and Molecular …
Y Qu, MJ Bloemink, J Reedijk… - Journal of the …, 1996 - ACS Publications
Dinuclear platinum complexes form a unique array of DNA adducts including (Pt, Pt)
interstrand and (Pt, Pt) intrastrand cross-links. A (Pt, Pt) intrastrand adduct between two …
interstrand and (Pt, Pt) intrastrand cross-links. A (Pt, Pt) intrastrand adduct between two …
Effects of Buffers and pH on the Reaction of a trans‐Platinum Complex with 5′‐Guanosine Monophosphate
C Li, Y Ding, L Cheng, Y Zheng… - European Journal of …, 2015 - Wiley Online Library
The aquation of platinum anticancer drugs is a crucial step for their activation and the
consequent binding to the target DNA. These processes can be influenced by small …
consequent binding to the target DNA. These processes can be influenced by small …
The interaction of peptide-tethered platinum (II) complexes with DNA
MS Robillard, NP Davies, GA van der Marel… - Journal of inorganic …, 2003 - Elsevier
The sequence specificity and intensity of DNA damage induced by six peptide-tethered
platinum complexes was compared to cisplatin and Pt (en) Cl2. DNA damage was …
platinum complexes was compared to cisplatin and Pt (en) Cl2. DNA damage was …
X-ray Crystal Structure of a Monofunctional Platinum–DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex
RC Todd, SJ Lippard - Platinum and Other Heavy Metal Compounds in …, 2009 - Springer
Features of the 2.17 Å resolution X-ray crystal structure of cis-diammine-(pyridine)
chloroplatinum (II)(cDPCP) bound in a monofunctional manner to deoxyguanosine in a DNA …
chloroplatinum (II)(cDPCP) bound in a monofunctional manner to deoxyguanosine in a DNA …
Unique platinum–DNA interactions may lead to more effective platinum-based antitumor drugs
S Komeda - Metallomics, 2011 - academic.oup.com
Platinum coordination compounds are among the most utilized anticancer agents, even
though platinum has not been determined to be an essential trace element in any living …
though platinum has not been determined to be an essential trace element in any living …
Preparation, characterization and cytotoxic activity of new compounds trans-[PtCl2NH3 (3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3 (4-(hydroxymethyl)-pyridine …
FJ Ramos-Lima, AG Quiroga, JM Pérez… - Polyhedron, 2003 - Elsevier
We report the synthesis, characterization and cytotoxic assays of new trans-platinum
compounds, trans-[PtCl2NH3 (3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3 (4 …
compounds, trans-[PtCl2NH3 (3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3 (4 …
Investigations of the Binding of [Pt2(DTBPA)Cl2](II) and [Pt2(TPXA)Cl2](II) to DNA via Various Cross-Linking Modes
H Yue, B Yang, Y Wang, G Chen - International Journal of Molecular …, 2013 - mdpi.com
We have constructed models for a series of platinum-DNA adducts that represent the
binding of two agents,[Pt2 (DTBPA) Cl2](II) and [Pt2 (TPXA) Cl2](II), to DNA via inter-and …
binding of two agents,[Pt2 (DTBPA) Cl2](II) and [Pt2 (TPXA) Cl2](II), to DNA via inter-and …
Insights into the structure–activity relationships of chiral 1, 2-diaminophenylalkane platinum (II) anticancer derivatives
The structure–activity relationships of chiral 1, 2-diaminophenylalkane platinum (II)
anticancer derivatives are studied, including interactions with telomeric-and genomic-like …
anticancer derivatives are studied, including interactions with telomeric-and genomic-like …
Synthesis, Structure, Biological Activity, and DNA Binding of Platinum(II) Complexes of the Type trans-[PtCl2(NH3)L] (L = Planar Nitrogen Base). Effect of L and Cis …
U Bierbach, Y Qu, TW Hambley, J Peroutka… - Inorganic …, 1999 - ACS Publications
In order to establish fundamental structural requirements for the antitumor activation of the
trans-platinum geometry, complexes of the general formulas [PtCl2 (NH3) L](L= planar N …
trans-platinum geometry, complexes of the general formulas [PtCl2 (NH3) L](L= planar N …
Studies on the Activity of Two Trans-Planaramine Platinum (II) Complexes Coded as DH4 and DH5 in Human Ovarian Tumour Models
N Deqnah, JQ Yu, P Beale, F Huq - Anticancer research, 2012 - ar.iiarjournals.org
In this article, we report the synthesis and the in vitro activity of trans-bis (2-methylimidazole)
dichloroplatinum (II)(coded as DH4) and trans-(ammino)(2, 3-diaminopyridine) …
dichloroplatinum (II)(coded as DH4) and trans-(ammino)(2, 3-diaminopyridine) …