Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand: Mechanistic studies on antitumor action
J Kasparkova, O Novakova, V Marini, Y Najajreh… - Journal of Biological …, 2003 - ASBMB
A paradigm for the structure-pharmacological activity relationship of bifunctional platinum
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …
antitumor drugs is that the trans isomer of antitumor cisplatin (transplatin) is clinically …
Replacement of an NH3 by an iminoether in transplatin makes an antitumor drug from an inactive compound
M Leng, D Locker, MJ Giraud-Panis, A Schwartz… - Molecular …, 2000 - ASPET
To investigate the modifications of antitumor activity and DNA binding mode of transplatin
after replacement of one nonleaving group NH3 by an iminoether group, trans-[PtCl2 {Z …
after replacement of one nonleaving group NH3 by an iminoether group, trans-[PtCl2 {Z …
Studies on Synthesis, Activity and Binding with DNA of a New Trinuclear Platinum Compound [{trans-PtCl (NH3) 2} 2 {trans-Pt (thiazole) 2}{H2N (CH2) 6 NH2} 2] Cl3 …
J Al-Shuneigat, Y Qing, P Beale, K Fisher… - Medicinal …, 2011 - ingentaconnect.com
A new trinuclear platinum compound [{trans-PtCl (NH3) 2} 2 {trans-Pt (thiazole) 2}{H2N
(CH2) 6NH2} 2] Cl3 (NO3) has been synthesized and characterized. The activity of the …
(CH2) 6NH2} 2] Cl3 (NO3) has been synthesized and characterized. The activity of the …
Modifications of the DNA secondary structure upon platinum binding: a proposed model
JP Macquet, JL Butour - Biochimie, 1978 - Elsevier
A number of physico-chemical techniques were used to study the interaction between a
series of platinum compounds and DNA. Spectrofluorometry, ultraviolet spectroscopy (UV) …
series of platinum compounds and DNA. Spectrofluorometry, ultraviolet spectroscopy (UV) …
DNA–protein cross‐linking by trans ‐[PtCl 2 ( E‐ iminoether) 2 ]. A concept for activation of the trans …
O Novakova, J Kasparkova, J Malina… - Nucleic acids …, 2003 - academic.oup.com
The structure–pharmacological activity relationships generally accepted for antitumor
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …
platinum compounds stressed the necessity for the cis‐[PtX 2 (amine) 2] structure while the …
Histone H1 interacts preferentially with DNA fragments containing a cisplatin-induced 1, 2-intrastrand cross-link
JN Yaneva, EG Paneva, SI Zacharieva… - … für Naturforschung C, 2007 - degruyter.com
Cisplatin [cis-diamminedichloroplatinum (II) or cis-DDP], but not its stereoisomer transplatin,
is suggested to be among the most powerful anticancer agents. It is believed that its …
is suggested to be among the most powerful anticancer agents. It is believed that its …
Mixed-metal polymetallic platinum complexes designed to interact with DNA
M Milkevitch, BW Shirley, KJ Brewer - Inorganica chimica acta, 1997 - Elsevier
Complexes of the general form [(bpy) 2M (dpb) PtCl2] Cl2 (where M RuII or OsII, bpy=
2.2′-bipyridine and dpb= 2, 3-bis (2-pyridyl) benzoquinoxaline) have been designed by our …
2.2′-bipyridine and dpb= 2, 3-bis (2-pyridyl) benzoquinoxaline) have been designed by our …
New insights about the interaction of cisplatinum with intracellular components
J Reedijk - Platinum and Other Metal Coordination Compounds in …, 1991 - Springer
The now classic antitumor compound cis-PtCl 2 (NH 3) 2 (abbreviated as cisPt) is known to
react with cellular components, such as DNA and proteins. Initially most attention was …
react with cellular components, such as DNA and proteins. Initially most attention was …
The interaction of platinum complexes with nucleosomes investigated with fluorescent probes
LM Thompson, M Arquilla, H Simpkins - Biochimica et Biophysica Acta …, 1982 - Elsevier
Abstract The fluorescent probes, N-(3-pyrene) maleimide, which is specific for histone H3,
and terbium (Tb 3+), which is specific for guanine single-stranded residues in DNA, are used …
and terbium (Tb 3+), which is specific for guanine single-stranded residues in DNA, are used …
DNA Cross‐Linking Patterns Induced by an Antitumor‐Active Trinuclear Platinum Complex and Comparison with Its Dinuclear Analogue
J Zhu, Y Zhao, Y Zhu, Z Wu, M Lin, W He… - … A European Journal, 2009 - Wiley Online Library
The center of it all: An antitumor‐active trinuclear platinum complex forms unprecedented
interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow …
interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow …