Apelin is highly expressed in the lungs, especially in the pulmonary vasculature, but the
functional role of apelin under pathological conditions is still undefined. Hypoxic pulmonary …

Chronic stress induces the activation of hippocampal microglia, which produces many
inflammatory mediators and mediates the occurrence of depression. Two phenotypes of …

Several experimental studies have proved that activation of neuroinflammation pathways
may contribute to the development of depression, a neuropsychiatric disorder disease. Our …

Background. Apelin alleviates oxidative stress which contributes to the development of
aging. IVDD is a disease closely correlated to aging and oxidative stress which is known to …

Purpose To explore the neuroprotective effects and mechanisms of Apelin (APLN), and to
study the regulation of APLN expression by microRNA (miRNA) in epilepsy. Materials and …

The apelin/APJ signaling is composed of the short peptide apelin usually including apelin-
13, apelin-17 and apelin-36, and its receptor APJ. This signaling is abundantly expressed in …

Objectives We investigated the effect of apelin-13 on the cellular model of AD, amyloid-β
(Aβ) treated SH-SY5Y cells in rats. Methods The SH-SY5Y cells were pretreated with …

This paper aims to observe the changes of the inflammatory cytokines in microglial BV2 cells
stimulated by apelin, and investigate the mechanism of inflammatory cytokines secretion …

Cerebral ischemia/reperfusion (I/R) injury-induced cellular apoptosis contributes to neuronal
death in ischemic stroke, while endoplasmic reticulum stress (ERS) and subsequently …

It has been shown that alcohol consumption by pregnant women can have detrimental
effects on the developing fetus and lead to fetal alcohol spectrum disorders (FASD) …