Stroke is one of the leading causes of death and disability worldwide, and ischemic stroke
accounts for approximately 87% of cases. Improving post-stroke recovery is a major …

Background Proliferation of vascular smooth muscle cells (VSMCs) plays a vital role in the
progression of vascular remodeling and hypertension. Apelin-13 promotes VSMC …

Background: The apelin-APJ system has been considered to play a crucial role in HPA axis
function, and how the traditional Chinese compound prescription Xiaoyaosan regulates the …

Apelin is the endogenous peptide APJ receptor, while APJ is a member of the G protein-
coupled receptors family. Recent evidence strongly suggests that Apelin/APJ system …

The aim of the present study was to investigate the effect of Apelin‑13 on autophagy in
hepatocellular carcinoma HepG2 cells and the underlying mechanism of the effect. The …

Apelin, a novel bioactive peptide highly concentrated in the brain, is identified as the
endogenous ligand for angiotensin-like 1 receptor (APJ). The present study was designed to …

Elabela (ELA), which is the second endogenous peptide ligand of the apelin receptor (APJ)
to be discovered, has been widely studied for potential use as a therapeutic peptide …

Apelin is the endogenous ligand of APJ receptor. Both monocytes (MCs) and human
umbilical vein endothelial cells (HUVECs) express apelin and APJ, which play important …

Apelin and its receptor APJ (apelin receptor) are prominently expressed in brain regions
involved in learning and memory. However, the role of apelin in cognition was largely …

Apelin-13 is extensively expressed in various tissues, particularly breast tissue. Apelin‑13
has been shown to promote tumor proliferation in various types of cancer, including …