[PDF][PDF] Aryl sulfonamides degrade RBM39 and RBM23 by recruitment to CRL4-DCAF15
Indisulam and related sulfonamides recruit the splicing factor RBM39 to the CRL4-DCAF15
E3 ubiquitin ligase, resulting in RBM39 ubiquitination and degradation. Here, we used a …
E3 ubiquitin ligase, resulting in RBM39 ubiquitination and degradation. Here, we used a …
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
INTRODUCTION Indisulam is an aryl sulfonamide drug that inhibits the proliferation of
certain human cancer cell lines. Its mechanism of action and the mechanism underlying its …
certain human cancer cell lines. Its mechanism of action and the mechanism underlying its …
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
DE Bussiere, L Xie, H Srinivas, W Shu, A Burke… - Nature Chemical …, 2020 - nature.com
The anticancer agent indisulam inhibits cell proliferation by causing degradation of RBM39,
an essential mRNA splicing factor. Indisulam promotes an interaction between RBM39 and …
an essential mRNA splicing factor. Indisulam promotes an interaction between RBM39 and …
[HTML][HTML] Transcriptome-wide targets of alternative splicing by RBM4 and possible role in cancer
This study determined transcriptome-wide targets of the splicing factor RBM4 using
Affymetrix GeneChip® Human Exon 1.0 ST Arrays and HeLa cells treated with RBM4 …
Affymetrix GeneChip® Human Exon 1.0 ST Arrays and HeLa cells treated with RBM4 …
Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are
frequently observed in lung adenocarcinoma (LUAD). We have previously shown that …
frequently observed in lung adenocarcinoma (LUAD). We have previously shown that …
Integrative analysis revealed the molecular mechanism underlying RBM 10‐mediated splicing regulation
Y Wang, A Gogol‐Döring, H Hu, S Fröhler… - EMBO molecular …, 2013 - embopress.org
RBM10 encodes an RNA binding protein. Mutations in RBM10 are known to cause multiple
congenital anomaly syndrome in male humans, the TARP syndrome. However, the …
congenital anomaly syndrome in male humans, the TARP syndrome. However, the …
Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models
Aberrant alternative pre-mRNA splicing plays a critical role in MYC-driven cancers and
therefore may represent a therapeutic vulnerability. Here, we show that neuroblastoma, a …
therefore may represent a therapeutic vulnerability. Here, we show that neuroblastoma, a …
Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5′ splice site selection
AY Zhou, AC Ou, A Cho, EJ Benz Jr… - Molecular and cellular …, 2008 - Taylor & Francis
RBM25 has been shown to associate with splicing cofactors SRm160/300 and assembled
splicing complexes, but little is known about its splicing regulation. Here, we characterize the …
splicing complexes, but little is known about its splicing regulation. Here, we characterize the …
Global regulation of alternative RNA splicing by the SR-rich protein RBM39
S Mai, X Qu, P Li, Q Ma, C Cao, X Liu - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Background RBM39 is a serine/arginine-rich RNA-binding protein that is highly homologous
to the splicing factor U2AF65. However, the role of RBM39 in alternative splicing is poorly …
to the splicing factor U2AF65. However, the role of RBM39 in alternative splicing is poorly …
RNA‐binding motif protein 39 (RBM39): An emerging cancer target
RNA‐binding motif protein 39 (RBM39) is an RNA‐binding protein involved in transcriptional
co‐regulation and alternative RNA splicing. Recent studies have revealed that RBM39 is the …
co‐regulation and alternative RNA splicing. Recent studies have revealed that RBM39 is the …