Background: The ubiquitin-proteasome pathway is crucial for all cellular processes and is,
therefore, a critical target for the investigation and development of novel strategies for cancer …

The ubiquitin proteasome pathway was discovered in the 1980s to be a central component
of the cellular protein-degradation machinery with essential functions in homeostasis, which …

A concept that currently steers the development of cancer therapies has been that agents
directed against specific proteins that facilitate tumorigenesis or maintain a malignant …

Background: The ubiquitin-proteasome system has become a promising novel molecular
target in cancer due to its critical role in cellular protein degradation, its interaction with cell …

Selective protein degradation by the ubiquitin–proteasome pathway (UPP) is critical to
cellular homeostasis, and dysregulation of the UPP has been associated with human …

Proteasome inhibitors have shown relevant clinical activity in several hematological
malignancies, namely in multiple myeloma and mantle cell lymphoma, improving patient …

The ubiquitin proteasome system was discovered in the 1980s, acting as the central
component of the intracellular protein-degradation process. The proteasome has been …

The degradation of intracellular proteins is targeted by ubiquitin via non-lysosomal
proteolytic pathway in the cell system. These ubiquitin molecules have been found to be …

The ubiquitin-proteasome pathway is a dynamic and complex cellular process that regulates
the levels of 80-90% of the proteins in the cell. To date, most of the pharmacological …

The ubiquitin proteasome pathway is the most significant intracellular proteolytic pathway.
The target proteins are usually ubiquitinated prior to degradation by the proteasome; …