Iodothyronine deiodinases (DIO) are a family of selenoproteins controlling systemic and
local availability of the major thyroid hormone l-thyroxine (T4), a prohormone secreted by the …

Thyroid hormones control growth, development, differentiation and metabolism in
vertebrates. Most of the actions of the active thyroid hormone T3 (3, 5, 3′-triiodo-l …

The thyroid hormone plays a fundamental role in the development, growth, and metabolic
homeostasis in all vertebrates by affecting the expression of different sets of genes. A group …

Thyroid hormone signaling is customized in a time and cell-specific manner by the
deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity,
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …

Thyroid hormone (TH) homeostasis depends on peripheral activation and inactivation of
iodothyronines by selenoenzymes of the deiodinase (Dio) family. We genetically inactivated …

BACKGROUND: Thyroid hormone signaling is critical for development, growth and
metabolic control in vertebrates. Although serum concentration of thyroid hormone is …

The human thyroid gland secretes thyroid hormones under the control of the hypothalamus-
pituitary-periphery feedback axis already during the last fetal trimester and is the only …

Iodothyronine deiodinases (D1, D2, and D3) comprise a family of selenoproteins that are
involved in the conversion of thyroxine (T4) to active triiodothyronine (T3), and also the …