Mucosal mast cells (MMCs) localized in the intestinal mucosa play a key role in the
development of IgE-mediated food allergies. Recent advances have revealed that MMCs …

Mast cells are distributed throughout the gastrointestinal tract and function as the main
effector cells of IgE-mediated allergic reactions to foods. Allergen-induced cross-linking of …

Mast cells (MCs) are cells of hematopoietic origin that normally reside in mucosal tissues,
often near epithelial cells, glands, smooth muscle cells, and nerves. Best known for their …

Mast cells have been considered for many years to participate specifically in allergic
reactions through the release of cytokines, chemokines, proteases, leukotrienes, and …

Mast cells (MC) are major effector cells of IgE-mediated allergic inflammation. However, it
has become increasingly clear that they also play important roles in a diversity of …

Food can trigger a diverse array of symptoms in food allergic individuals from isolated local
symptoms affecting skin or gut to multi-system severe reactions (systemic anaphylaxis) …

Background This study group has previously identified IL-9–producing mucosal mast cell
(MMC9) as the primary source of IL-9 to drive intestinal mastocytosis and experimental IgE …

Mast cells (MCs) are major effector cells of immunoglobulin E (IgE)‐mediated allergic
inflammation. However, it has become increasingly clear that they also play important roles …

Oral immunotherapy (OIT) is an effective approach to controlling food allergy. Although the
detailed molecular and cellular mechanisms of OIT are unknown currently, they must be …

To achieve immune homeostasis in such a harsh environment as the intestinal mucosa, both
active and quiescent immunity operate simultaneously. Disruption of gut immune …