Adipose-derived stem cells promote peripheral nerve regeneration in vivo without differentiation into Schwann-like lineage

Y Sowa, T Kishida, T Imura, T Numajiri… - Plastic and …, 2016 - journals.lww.com
Background: During recent decades, multipotent stem cells were found to reside in the
adipose tissue, and these adipose-derived stem cells were shown to play beneficial roles …

Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush

S Marconi, G Castiglione, E Turano… - … Engineering Part A, 2012 - liebertpub.com
Mesenchymal stem cells (MSCs) represent a promising therapeutic approach in nerve tissue
engineering. To date, the local implantation of MSC in injured nerves has been the only …

The protection of MSCs from apoptosis in nerve regeneration by TGFβ1 through reducing inflammation and promoting VEGF-dependent angiogenesis

H Luo, Y Zhang, Z Zhang, Y Jin - Biomaterials, 2012 - Elsevier
Our previous report demonstrated that autologous adipose-derived mesenchymal stem cells
(ADSCs) combined with xenogeneic acellular nerve matrix (XANM) can support the …

Adipose-derived stem cells produce factors enhancing peripheral nerve regeneration: influence of age and anatomic site of origin

Y Sowa, T Imura, T Numajiri, K Nishino… - Stem cells and …, 2012 - liebertpub.com
Adipose-derived stem cells (ADSCs) are attracting increased attention as a novel source in
regenerative medicine. Transplantation of ADSCs promotes functional recovery in animal …

Peripheral Nerve Regeneration–Adipose-Tissue-Derived Stem Cells Differentiated by a Three-Step Protocol Promote Neurite Elongation via NGF Secretion

S Klein, A Siegmund, A Eigenberger, V Hartmann… - Cells, 2022 - mdpi.com
The lack of supportive Schwann cells in segmental nerve lesions seems to be one
cornerstone for the problem of insufficient nerve regeneration. Lately, adipose-tissue …

Augmenting peripheral nerve regeneration with adipose-derived stem cells

L Jiang, T Mee, X Zhou, X Jia - Stem cell reviews and reports, 2022 - Springer
Peripheral nerve injuries (PNIs) are common and debilitating, cause significant health care
costs for society, and rely predominately on autografts, which necessitate grafting a nerve …

Adipose-derived stem cells and nerve regeneration: promises and pitfalls

A Faroni, G Terenghi, AJ Reid - International review of neurobiology, 2013 - Elsevier
In order to improve the outcome of nerve regeneration following peripheral trauma injuries,
the development of bioengineered nerve grafts has attracted great attention in the field of …

Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration

Y Wang, Z Zhao, Z Ren, B Zhao, L Zhang, J Chen… - Neuroscience …, 2012 - Elsevier
Chemical-extracted acellular nerve allografting, containing the natural nerve structure and
elementary nerve extracellular matrix (ECM), has been used for peripheral nerve-defect …

Induction of adipose-derived stem cells into Schwann-like cells and observation of Schwann-like cell proliferation

X Fu, Z Tong, Q Li, Q Niu, Z Zhang… - Molecular …, 2016 - spandidos-publications.com
The peripheral nervous system has the potential for full regeneration following injury and
recovery, predominantly controlled by Schwann cells (SCs). Therefore, obtaining a sufficient …

Extracellular matrix molecules enhance the neurotrophic effect of Schwann cell-like differentiated adipose-derived stem cells and increase cell survival under stress …

PG di Summa, DF Kalbermatten, W Raffoul… - … Engineering Part A, 2013 - liebertpub.com
Since the first reports of induction of adipose-derived stem cells (ASC) into neuronal and
glial cell phenotypes, expectations have increased regarding their use in tissue engineering …