Protective effect of brain-derived neurotrophic factor and neurotrophin-3 overexpression by adipose-derived stem cells combined with silk fibroin/chitosan scaffold in …

WC Ji, M Li, WT Jiang, X Ma, J Li - Neurological Research, 2020 - Taylor & Francis
Objectives: Spinal cord injury (SCI) is a most debilitating traumatic injury, and cytotherapy is
a promising alternative treatment strategy. Here we investigated the effect and mechanism of …

Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves

M Pan, X Wang, Y Chen, S Cao, J Wen, G Wu, Y Li… - Experimental …, 2017 - Elsevier
Peripheral nerve injury repair can be enhanced by Schwann cell (SC) transplantation, but
clinical applications are limited by the lack of a cell source. Thus, alternative systems for …

Sciatic nerve regeneration by cocultured Schwann cells and stem cells on microporous nerve conduits

LG Dai, GS Huang, S Hsu - Cell transplantation, 2013 - journals.sagepub.com
Cell transplantation is a useful therapy for treating peripheral nerve injuries. The clinical use
of Schwann cells (SCs), however, is limited because of their limited availability. An emerging …

Regeneration potential and survival of transplanted undifferentiated adipose tissue-derived stem cells in peripheral nerve conduits

P Erba, C Mantovani, DF Kalbermatten, G Pierer… - Journal of Plastic …, 2010 - Elsevier
Adipose tissue-derived stem cells (ADSCs) have shown potential for the treatment of nerve
injuries. Most previous efforts have aimed at stimulating regeneration by using neural …

[HTML][HTML] Adipose stem cell-derived extracellular vesicles induce proliferation of Schwann cells via internalization

M Haertinger, T Weiss, A Mann, A Tabi, V Brandel… - Cells, 2020 - mdpi.com
Recent studies showed a beneficial effect of adipose stem cell-derived extracellular vesicles
(ADSC-EVs) on sciatic nerve repair, presumably through Schwann cell (SC) modulation …

Neuronal differentiation of human adipose tissue–derived stem cells for peripheral nerve regeneration in vivo

T Scholz, A Sumarto, A Krichevsky… - Archives of …, 2011 - jamanetwork.com
Objective: To evaluate the ability of a tissue-engineered nerve construct composed of a
nerve guidance channel and neurally differentiated human adipose tissue–derived stem …

Regenerative effect of adipose tissue‐derived stem cells transplantation using nerve conduit therapy on sciatic nerve injury in rats

BS Liu, YC Yang, CC Shen - Journal of tissue engineering and …, 2014 - Wiley Online Library
This study proposed a biodegradable GGT nerve conduit containing genipin crosslinked
gelatin annexed with tricalcium phosphate (TCP) ceramic particles for the regeneration of …

Newly generated 3D Schwann-like cell spheroids from human adipose-derived stem cells using a modified protocol

S Chen, T Ikemoto, T Tokunaga… - Cell …, 2022 - journals.sagepub.com
Peripheral nerve injury (PNI) is a relatively frequent type of trauma that results in the
suffering of many patients worldwide every year. Schwann cells (SCs) are expected to be …

Stimulating the neurotrophic and angiogenic properties of human adipose-derived stem cells enhances nerve repair

PJ Kingham, MK Kolar, LN Novikova… - Stem cells and …, 2014 - liebertpub.com
In future, adipose-derived stem cells (ASC) might be used to treat neurological disorders. In
this study, the neurotrophic and angiogenic properties of human ASC were evaluated, and …

[HTML][HTML] Effects of adipose derived stem cells pretreated with resveratrol on sciatic nerve regeneration in rats

Z Zhang, M Zhang, Y Sun, M Li, C Chang, W Liu… - Scientific Reports, 2023 - nature.com
Adipose derived stem cells (ADSCs) are popular in regenerative medicine due to their easy
availability, low immunogenicity and lack of controversy regarding their ethical debate use …