Pontospinal noradrenergic neurons form a component of an endogenous analgesic system
and represent a potential therapeutic target. We tested the principle that genetic …

The spinal dorsal horn receives a dense innervation of noradrenaline‐containing fibers that
originate from pontine neurons in the A5, locus coeruleus (LC), and A7 cell groups. These …

Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …

Study Design. A prospective in vivo animal study. Objectives. To examine the effect of the
proenkephalin and glutamic acid decarboxylase (GAD)-expressing herpes simplex virus …

Neurons in the rostral ventromedial medulla (RVM) project to the spinal cord and are
involved in descending modulation of pain. Several studies have shown that activation of …

Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to
modulate a wide range of processes including attention, arousal, autonomic control and …

Second-order spinal cord excitatory neurons play a key role in spinal processing and
transmission of pain signals to the brain. Exogenously induced change in developmentally …

Background: A chronic compressed dorsal root ganglion (CCD) in rat produces pain
behavior and an enhanced excitability of neurons within the compressed ganglion. Kir2. 1 is …

Pontospinal noradrenergic neurons form part of an endogenous analgesic system that
suppresses acute pain, but there is conflicting evidence about its role in neuropathic pain …

Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and
can either increase or decrease nociception depending on physiological context. It is …