[HTML][HTML] Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway

Y Li, Y Liu, Z Chen, K Tang, L Yang, Y Jiang… - Biomedicine & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has become one of the main chronic liver
diseases worldwide. Protopanaxadiol (PPD), an active compound derived from …

Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay

M Hong, Z Cai, L Song, Y Liu, Q Wang… - Evidence‐Based …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in
developed countries. Oxidative stress plays a critical role in the progression of NAFLD …

[HTML][HTML] β-patchoulene improves lipid metabolism to alleviate non-alcoholic fatty liver disease via activating AMPK signaling pathway

N Xu, H Luo, M Li, J Wu, X Wu, L Chen, Y Gan… - Biomedicine & …, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) has been a leading cause of chronic metabolic
disease, seriously posing healthy burdens to the public, whereas interventions available for …

Gypenosides counteract hepatic steatosis and intestinal barrier injury in rats with metabolic associated fatty liver disease by modulating the adenosine …

S Shen, K Wang, Y Zhi, Y Dong - Pharmaceutical Biology, 2022 - Taylor & Francis
Context Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease,
can develop into metabolic associated fatty liver disease (MAFLD). Gypenosides (GP), the …

Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis

R Huang, F Guo, Y Li, Y Liang, G Li, P Fu, L Ma - Phytomedicine, 2021 - Elsevier
Background Triptolide is naturally isolated from Tripterygium wilfordii Hook F., possessing
multiple biological activities. Hepatotoxicity is one of the main side effects of triptolide …

Tetrahydropalmatine ameliorates hepatic steatosis in nonalcoholic fatty liver disease by switching lipid metabolism via AMPK-SREBP-1c-Sirt1 signaling axis

X Yin, Z Liu, J Wang - Phytomedicine, 2023 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) is becoming a global epidemic without
effective treatment currently available. NAFLD is characterized by an increase in hepatic de …

Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism

T Zhou, L Cao, Y Du, L Qin, Y Lu, Q Zhang, Y He… - PeerJ, 2023 - peerj.com
Gypenosides (GP), extracted from the traditional Chinese herb Gynostemma pentaphyllum
(Thunb.) Makino, have been used to treat metabolic disorders, including lipid metabolism …

Asperuloside alleviates lipid accumulation and inflammation in HFD-induced NAFLD via AMPK signaling pathway and NLRP3 inflammasome

Q Shen, Y Chen, J Shi, C Pei, S Chen, S Huang… - European Journal of …, 2023 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is a clinical pathological syndrome of
hepatic parenchymal cell steatosis caused by excessive lipid deposition, which is the …

[HTML][HTML] Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway

N Li, L Yin, J Shang, M Liang, Z Liu, H Yang… - Biomedicine & …, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases with
limited treatment options. Moreover, its prevalence is doubled in type 2 diabetes mellitus …

Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway

Y Gu, S Duan, M Ding, Q Zheng, G Fan, X Li, Y Li, C Liu… - Phytomedicine, 2022 - Elsevier
Background Metabolic associated fatty liver disease (MAFLD) is a progressive chronic liver
disease, yet there is still a lack of effective pharmacological therapies at present …