Alzheimer's disease (AD) is a progressive disease with early degeneration of the central
cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine …

Introduction Alzheimer's disease (AD) is the most prevalent form of dementia with symptoms
of deteriorating cognitive functions and memory loss, partially as a result of a decrease in …

The clinical significance and the effects of pharmacological treatment of patients with
Alzheimer's disease (AD) were evaluated by measurement of acetylcholinesterase (AChE) …

Parnetti L, Chiasserini D, Andreasson U, Ohlson M, Hüls C, Zetterberg H, Minthon L, Wallin
ÅK, Andreasen N, Talesa VN, Blennow K. Changes in CSF acetyl‐and butyrylcholinesterase …

Although the neurodegeneration occurring in Alzheimer's disease (AD) affects multiple
neurotransmitters, the cholinergic system has received the greatest attention. Acetylcholine …

The relationship between acetylcholinesterase (AChE) activity in the CSF and brain of
patients with Alzheimer's disease (AD) was investigated in 18 mild AD patients following …

Background: The cholinergic hypothesis is well established and has led to the development
of pharmacological treatments for Alzheimer's disease (AD). However, there has previously …

Background Cholinergic neurons utilize choline (Ch) to synthetize acetylcholine (ACh) and
contain a high-affinity Ch transporter, Ch acetyltransferase (ChAT), ACh receptors, and …

Introduction The extensive loss of central cholinergic functions in Alzheimer's disease (AD)
brain is linked to impaired nerve growth factor (NGF) signaling. The cardinal cholinergic …

Objective The main objective of this study was to investigate possible predictors of response
to cholinesterase inhibitor (ChEI) treatment, including pre‐treatment progression rates and …