Cholinergic neurotransmission is essential for cognitive processes in the human brain and
was found to be disturbed in Alzheimer's disease. Since Alzheimer's disease is associated …

Cerebral β-amyloid (cAβ) deposition and cholinergic dysfunction have been considered as
major pathological and functional hallmarks of Alzheimer's disease (AD) …

Objective: To validate an in vivo method for mapping acetylcholinesterase (AChE) activity in
human brain, preparatory to monitoring inhibitor therapy in AD. Background: AChE activity is …

Protein levels of different acetylcholinesterase (AChE) splice variants were explored by a
combination of immunoblot techniques, using two different antibodies, directed against the C …

Background: The current study aimed to compare the effects of different cholinesterase
inhibitors on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities and …

Aims Cholinesterase inhibitors (CEIs) have been shown to improve cognitive functioning in
Alzheimer's disease (AD) patients, but are associated with multiple side effects and only 20 …

SAMPLES of cerebrospinal fluid (CSF) were examined, looking mainly at total
cholinesterase (ChE) and acetylcholinesterase (AChE) levels from 139 living subjects. At the …

The cholinergic system is crucial for cognitive processes and the deficient acetylcholine
(ACh) function has been implicated in Alzheimer's disease (AD). Inhibitors of …

The so-called “cholinergic hypothesis” assumes that degenerative dysfunction of the
cholinergic system originating in the basal forebrain and innervating several cortical regions …

Background Early-onset Alzheimer's disease (EOAD), defined by age of onset below 65,
and late-onset Alzheimer's disease (LOAD), defined by age of onset above 65 differs in …