Small airway disease is recognized as a cardinal pathological process of chronic obstructive
pulmonary disease (COPD), and recently small airways have been recognized as a major …

Background/Objectives: Several studies have demonstrated the positive clinical and
functional impact of adding Long-Acting Muscarinic Antagonist (LAMA) to Inhaled …

Asthma and COPD have a high personal, societal, and economic impact. Both diseases are
characterized by airway obstruction and an inflammatory process. The inflammatory process …

Involvement of small airways, those of< 2 mm in internal diameter, is present in all stages of
asthma and contributes substantially to its pathophysiologic expression. Therefore, small …

COPD and asthma have different risk factors and pathogenesis, but they share a
pathophysiologic hallmark characterized by small airways disease. Although difficult to …

Evidence that enables us to identify, assess, and access the small airways in asthma and
chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma …

Asthma is a chronic disease, affecting approximately 350 million people worldwide.
Inflammation and remodeling in asthma involve the large airways, and it is now widely …

For more than 50 years, small airways disease has been considered a key feature of chronic
obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both …

Identification of pathologic changes in early and mild obstructive lung disease has shown
the importance of the small airways and their contribution to symptoms. Indeed, significant …

Traditionally, asthma has been considered a disease that predominantly involves the large
airways. Today, this concept is being challenged, and increasing evidence has become …