To evaluate the regional delivery of conventional aerosol medications, a new whole-lung
computational fluid dynamics modeling approach was applied for metered dose inhaler …

Asthma is a lung disease characterized by inflammation and remodeling of the airways,
which leads to airflow obstruction and symptoms of wheeze, chest tightness, cough and …

Asthma is characterized by inflammation of proximal and distal airways. As new formulations
of extrafine aerosol particles have become available, targeting small airways for the …

Introduction There is increasing evidence that tiotropium, a long-acting muscarinic agent
(LAMA), is useful in the presence of severe-uncontrolled asthma despite the optimization of …

Despite the wealth of experience in the management of asthma, the disease remains
inadequately controlled in some patients, who face long-term respiratory impairment and …

In 2011, severe asthma and/or insufficient control of disease remain major challenges for the
pulmonologist [1]. Small airway involvement has been demonstrated by a number of studies …

Introduction: Higher parasympathetic tone has been reported in asthmatics. In general,
cholinergic contractile tone is increased by airway inflammation associated with asthma …

Studies now show that treating the peripheral airways with smaller drug particle aerosols
certainly achieve comparable efficacy (and some studies show superiority) compared with …

Passive dry-powder inhalers (DPIs) have been developed as an alternative to pressurised
metered-dose inhalers (pMDIs) to improve aerosol delivery on inhalation and eliminate the …

Background Bronchodilator responsiveness (BDR) using FEV1 is often utilised to separate
COPD patients from asthmatics, although it can be present in some COPD patients. With the …