Calcific aortic valve disease (CAVD) is the most common disorder affecting heart valves and
is characterized by thickening, fibrosis and mineralization of the aortic valve leaflets …

Abstract Purpose of Review This review aims to highlight the past and more current literature
related to the multifaceted pathogenic programs that contribute to calcific aortic valve …

Calcific aortic valve disease (CAVD) is the most frequent heart valve disorder. It is
characterized by an active remodeling process accompanied with valve mineralization, that …

Calcific aortic valve disease (CAVD), previously thought to represent a passive
degeneration of the valvular extracellular matrix (VECM), is now regarded as an intricate …

Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …

Calcific aortic valve disease (CAVD) increasingly afflicts our aging population. One third of
our elderly have echocardiographic or radiological evidence of calcific aortic valve sclerosis …

Calcification occurs in atherosclerotic vascular lesions and in the aortic valve. Calcific aortic
valve disease (CAVD) is a slow, progressive disorder that ranges from mild valve thickening …

Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy
exists outside of prosthetic replacement. The increasing proportion of younger and more …