[HTML][HTML] ATYPICAL HEMOLYTIC UREMIC SYNDROME AND C3 GLOMERULOPATHY: CONCLUSIONS FROM A «KIDNEY DISEASE: IMPROVING GLOBAL …

THJ Goodship, HT Cook, F Fakhouri… - Nephrology (Saint …, 2018 - journal.nephrolog.ru
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

[HTML][HTML] Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes”(KDIGO) Controversies …

THJ Goodship, HT Cook, F Fakhouri, FC Fervenza… - Kidney international, 2017 - Elsevier
In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

C3 glomerulopathy and atypical hemolytic uremic syndrome: an updated review of the literature on alternative complement pathway disorders

K Turkmen, I Baloglu, H Ozer - International Urology and Nephrology, 2021 - Springer
The complement system plays a significant role within the pathological process of C3
glomerulopathy (C3GP) and atypical hemolytic uremic syndrome (aHUS). In daily practice …

# 1276 Clinical practice of complement inhibitor use in hemolytic uremic syndrome: findings from the European rare kidney disease registry

A Vujovic - Nephrology Dialysis Transplantation, 2024 - academic.oup.com
Abstract Background and Aims Over the last decade, significant advancements have
emerged in the field of rare kidney diseases, notably the introduction of C5 inhibitor therapy …

Outcome of atypical hemolytic uremic syndrome: role of triggers and complement abnormalities in the response to C5 inhibition

G Ardissino, D Cresseri, MC Mancuso, V Capone… - Journal of …, 2024 - Springer
Background Atypical-hemolytic uremic syndrome (aHUS) is a rare thrombotic
microangiopathy often due to uncontrolled complement activation, characterized by high risk …

The Complex Landscape of Factor H and Factor I Rare Variants in Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy: PO1320

V Fremeaux-Bacchi, MS Meuleman… - Journal of the …, 2021 - journals.lww.com
Background: Complement genetics has been extensively studied to dissect the
pathophysiology of atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy …

[HTML][HTML] Genetic abnormalities in biopsy-proven, adult-onset hemolytic uremic syndrome and C3 glomerulopathy

L Haydock, AP Garneau, L Tremblay, HY Yen… - Journal of Molecular …, 2022 - Springer
Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) have been
linked to mutations in many of the proteins that are involved in alternative complement …

Genetic and protein structural evaluation of atypical hemolytic uremic syndrome and C3 glomerulopathy

SJ Perkins - Advances in Chronic Kidney Disease, 2020 - Elsevier
Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) are associated
with loss of regulation of the alternative pathway of complement and its resulting …

Evolving complexity of complement-related diseases: C3 glomerulopathy and atypical haemolytic uremic syndrome

HT Cook - Current Opinion in Nephrology and Hypertension, 2018 - journals.lww.com
Recent work has provided new insights into the causes of C3 glomerulopathy and aHUS,
and the mechanism by which complement is dysregulated. This is of particular importance …

[PDF][PDF] An observational, non-interventional, multicenter, multinational registry of patients with atypical hemolytic uremic syndrome: initial patient characteristics

C Licht, G Ardissino, G Ariceta, J Beauchamp… - ASN Kidney Week …, 2013 - biblio.ugent.be
• Atypical hemolytic uremic syndrome (aHUS) is a genetic, progressive, life-threatening
disease mostly resulting from chronic, uncontrolled complement activation. It is …