Obesity is associated with several chronic comorbidities, one of which is type 2 diabetes
mellitus (T2DM). The pathogenesis of obesity and T2DM is influenced by alterations in diet …

Introduction: The biggest risk factor for obesity and its associated comorbidities is a Western
diet. This Western diet induces adipose tissue (AT) inflammation, which causes an AT …

We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-
injected and KKAy obese diabetic mice. These mice were pair-fed three different types of …

Excess consumption of energy-dense foods combined with a sedentary lifestyle is driving an
obesity epidemic. Although obesity is closely associated with insulin resistance, most …

In diabetes, pancreatic β-cells gradually lose their ability to secrete insulin with disease
progression. β-cell dysfunction is a contributing factor to diabetes severity. Recently, islet cell …

Objectives The carbohydrate-insulin model (CIM) predicts that increases in fasting and post-
prandial insulin in response to dietary carbohydrates stimulate energy intake and lower …

Aim The influence of dietary carbohydrates and fats on weight gain is inconclusively
understood. We studied the acute impact of these nutrients on the overall metabolic state …

Overfeeding of a hypercaloric diet leads to obesity, diabetes, chronic inflammation, and fatty
liver disease. Although limiting fat or carbohydrate intake is the cornerstone for obesity …

Although obesity is often associated with high-fat diets, it can develop from a variety of meal
patterns. Excessive intake of simple carbohydrates is one consistent eating behavior leading …

High fat feeding in rodents generally leads to obesity and insulin resistance whereas in
humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect …