Microfluidic droplet-assisted fabrication of vessel-supported tumors for preclinical drug discovery
High-fidelity in vitro tumor models are important for preclinical drug discovery processes.
Currently, the most commonly used model for in vitro drug testing remains the two …
Currently, the most commonly used model for in vitro drug testing remains the two …
All‐in‐one microfluidic design to integrate vascularized tumor spheroid into high‐throughput platform
The development of a scalable and highly reproducible in vitro tumor microenvironment
(TME) platform still sheds light on new insights into cancer metastasis mechanisms and …
(TME) platform still sheds light on new insights into cancer metastasis mechanisms and …
Microfluidics enabled bottom-up engineering of 3D vascularized tumor for drug discovery
Development of high-fidelity three-dimensional (3D) models to recapitulate the tumor
microenvironment is essential for studying tumor biology and discovering anticancer drugs …
microenvironment is essential for studying tumor biology and discovering anticancer drugs …
[HTML][HTML] On-chip modeling of tumor evolution: Advances, challenges and opportunities
C Li, JB Holman, Z Shi, B Qiu, W Ding - Materials Today Bio, 2023 - Elsevier
Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …
3D microengineered vascularized tumor spheroids for drug delivery and efficacy testing
Tumor angiogenesis is regarded as a promising target for limiting cancer progression
because tumor-associated vasculature supplies blood and provides a path for metastasis …
because tumor-associated vasculature supplies blood and provides a path for metastasis …
Tumor-microenvironment-on-a-chip for evaluating nanoparticle-loaded macrophages for drug delivery
Targeted drug delivery remains attractive but challenging for cancer therapy. Cell-mediated
drug delivery has emerged as a promising strategy to improve targeted drug delivery to …
drug delivery has emerged as a promising strategy to improve targeted drug delivery to …
Droplet microfluidics-based fabrication of monodisperse poly (ethylene glycol)-fibrinogen breast cancer microspheres for automated drug screening applications
Spheroidal cancer microtissues are highly advantageous for a wide range of biomedical
applications, including high-throughput drug screening, multiplexed target validation …
applications, including high-throughput drug screening, multiplexed target validation …
Engineering tumor vasculature on an injection-molded plastic array 3D culture (IMPACT) platform
Recent advances in microfluidic organ-on-a-chip technology have enabled the growth of 3D
microphysiological systems for diverse biological studies. Fabrication and usage limitations …
microphysiological systems for diverse biological studies. Fabrication and usage limitations …
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
Droplet microfluidics for tumor drug‐related studies and programmable artificial cells
P Dimitriou, J Li, G Tornillo, T McCloy… - Global …, 2021 - Wiley Online Library
Anticancer drug development is a crucial step toward cancer treatment, that requires realistic
predictions of malignant tissue development and sophisticated drug delivery. Tumors often …
predictions of malignant tissue development and sophisticated drug delivery. Tumors often …