Importance Combining antidepressants is frequently done in the treatment of acute
depression, but studies have yielded conflicting results. Objective To conduct a systematic …

Objective: Combining antidepressants (ADs) for therapy of acute depression is frequently
employed, but randomized studies have yielded conflicting results. We conducted a …

The objective was to perform a systematic review and meta-analysis of studies that
assessed the effect of the combination of antidepressants from the beginning of the …

Antidepressant–placebo response-differences (RDs) in controlled trials have been
declining, potentially confounding comparisons among older and newer drugs. For clinically …

Background Major depressive disorder is one of the most common, burdensome, and costly
psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological …

Introduction Many antidepressants are indicated for the treatment of major depression. Two
network meta-analyses have provided the most comprehensive assessments to date …

Background The present meta-analysis aimed to examine to what extent combined
pharmacotherapy with psychotherapy results in a different response to treatment compared …

Objectives: To examine the available scientific literature for answers to clinically relevant
questions regarding the effectiveness and tolerability of antidepressant drugs (ADs) for the …

Objective: Two antidepressant medication combinations were compared with selective
serotonin reuptake inhibitor monotherapy to determine whether either combination …

Objective: Many patients with depression remain poorly responsive to antidepressant
monotherapy. One approach for managing treatment-resistant depression is to combine …