[HTML][HTML] Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
S Du, H Zheng - Cell & bioscience, 2021 - Springer
Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …
of life-saving medicines, our life expectancy has increased substantially across the world in …
[HTML][HTML] Therapeutic strategies targeting FOXO transcription factors
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …
processes and in various pathological conditions, including cardiovascular disease, cancer …
[HTML][HTML] FOXO transcriptional factors and long-term living
Several pathologies such as neurodegeneration and cancer are associated with aging,
which is affected by many genetic and environmental factors. Healthy aging conceives …
which is affected by many genetic and environmental factors. Healthy aging conceives …
Characterization of the direct targets of FOXO transcription factors throughout evolution
FOXO transcription factors (FOXO s) are central regulators of lifespan across species, yet
they also have cell‐specific functions, including adult stem cell homeostasis and immune …
they also have cell‐specific functions, including adult stem cell homeostasis and immune …
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …
FOXO transcription factors as therapeutic targets in human diseases
A Orea-Soufi, J Paik, J Bragança, TA Donlon… - Trends in …, 2022 - cell.com
Forkhead box (FOX) O proteins are transcription factors (TFs) with four members in
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …
mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in …
FOXO3: a major gene for human longevity-a mini-review
Background: The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3),
is one of only two for which genetic polymorphisms have exhibited consistent associations …
is one of only two for which genetic polymorphisms have exhibited consistent associations …
The foxo code
Abstract The FoxO family of Forkhead transcription factors plays an important role in
longevity and tumor suppression by upregulating target genes involved in stress resistance …
longevity and tumor suppression by upregulating target genes involved in stress resistance …
FOXO1: a potential target for human diseases
H Lu, H Huang - Current drug targets, 2011 - ingentaconnect.com
The forkhead box O (FoxO) transcription factors are known to be involved in many
physiological and pathological processes including apoptosis, cell cycle arrest, stress …
physiological and pathological processes including apoptosis, cell cycle arrest, stress …
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …
pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in …