The anti-aging function of Klotho gene has been implicated in age-related diseases. The
physiological importance of Klotho in the progression of arterial stiffness with aging …

The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the
circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging …

The prevalence of arterial stiffness increases with age, whereas the level of the aging-
suppressor protein klotho decreases with age. The objective of this study is to assess …

Background & Objective. The prevalence of arterial stiffness increases with age while the
klotho level decreases with age. Klotho deficiency increases circulating aldosterone levels …

Background Low levels of the Klotho protein are associated with accelerated tissue aging,
including arterial stiffness, in patients with cardiovascular and renal diseases. However, this …

Background Klotho was originally identified in a mutant mouse strain unable to express the
gene that consequently showed shortened life spans. In humans, low serum Klotho levels …

Klotho was originally discovered as an aging-suppressor gene. The objective of this study is
to investigate whether klotho gene deficiency affects high-fat diet (HFD)–induced arterial …

Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and
arterial stiffness. We aimed to investigate associations between the serum klotho …

The human aging process is associated with vascular endothelial dysfunction. However,
humoral factors which might protect against endothelial dysfucntion during aging have not …

The Klotho gene, identified as an 'aging suppressor'gene, encodes a single-pass
transmembrane protein. The extracellular domain of Klotho is cleaved and released in the …