Progress in the mechanism and targeted drug therapy for COPD
C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
[HTML][HTML] Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities
I Bernardo, S Bozinovski, R Vlahos - Pharmacology & therapeutics, 2015 - Elsevier
Chronic obstructive pulmonary disease (COPD) is an incurable global health burden and is
characterised by progressive airflow limitation and loss of lung function. In addition to the …
characterised by progressive airflow limitation and loss of lung function. In addition to the …
Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease
SO Rodrigues, CMC Cunha, GMV Soares, PL Silva… - Pharmaceuticals, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …
New anti-inflammatory targets for chronic obstructive pulmonary disease
PJ Barnes - Nature reviews Drug discovery, 2013 - nature.com
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of
the peripheral airways and lung parenchyma, which leads to progressive obstruction of the …
the peripheral airways and lung parenchyma, which leads to progressive obstruction of the …
[HTML][HTML] Oxidative stress-based therapeutics in COPD
PJ Barnes - Redox biology, 2020 - Elsevier
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …
Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
CA Brandsma, M Van den Berge… - The Journal of …, 2020 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …
personal and societal burden. Exposure to toxic particles and gases, including cigarette …
Future research directions in chronic obstructive pulmonary disease
TL Croxton, GG Weinmann, RM Senior… - American journal of …, 2002 - atsjournals.org
Between 3 and 7 million Americans are currently diagnosed with chronic obstructive
pulmonary disease (COPD), and the true prevalence is probably greater than 16 million (1) …
pulmonary disease (COPD), and the true prevalence is probably greater than 16 million (1) …
New treatments for COPD
PJ Barnes - Nature reviews Drug discovery, 2002 - nature.com
COPD is one of the most common diseases in the world, and there is a global increase in
prevalence, but there are no drugs available at present that halt the relentless progression of …
prevalence, but there are no drugs available at present that halt the relentless progression of …
Chronic obstructive pulmonary disease: new opportunities for drug development
PJ Barnes - Trends in pharmacological sciences, 1998 - cell.com
Chronic obstructive pulmonary disease (COPD) is common and there is an increasing
worldwide prevalence. There are no available treatments to prevent the progression of …
worldwide prevalence. There are no available treatments to prevent the progression of …