Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells
Y Kubohara, Y Fukunaga, A Shigenaga… - International Journal of …, 2024 - mdpi.com
Differentiation-inducing factor 1 (DIF-1), found in Dictyostelium discoideum, has
antiproliferative and glucose-uptake-promoting activities in mammalian cells. DIF-1 is a …
antiproliferative and glucose-uptake-promoting activities in mammalian cells. DIF-1 is a …
Dictyostelium differentiation‐inducing factor‐1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells
W Omata, H Shibata, M Nagasawa, I Kojima… - The FEBS …, 2007 - Wiley Online Library
The differentiation‐inducing factor‐1 (DIF‐1) is a signal molecule that induces stalk cell
formation in the cellular slime mold Dictyostelium discoideum, while DIF‐1 and its analogs …
formation in the cellular slime mold Dictyostelium discoideum, while DIF‐1 and its analogs …
Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity
T Matsuda, F Takahashi-Yanaga, T Yoshihara… - Journal of …, 2010 - Elsevier
We have reported that the differentiation-inducing factors (DIFs) DIF-1 and DIF-3,
morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer …
morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer …
Oral administration of Dictyostelium differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin-induced diabetic rats
R Kawaharada, A Nakamura, K Takahashi, H Kikuchi… - Life sciences, 2016 - Elsevier
Aims Differentiation-inducing factor 1 (DIF-1), originally discovered in the cellular slime mold
Dictyostelium discoideum, and its derivatives possess pharmacological activities, such as …
Dictyostelium discoideum, and its derivatives possess pharmacological activities, such as …
Dictyostelium Differentiation-Inducing Factor-1 Promotes Glucose Uptake, at Least in Part, via an AMPK-Dependent Pathway in Mouse 3T3-L1 Cells
Y Kubohara, Y Homma, H Shibata, Y Oshima… - International journal of …, 2021 - mdpi.com
Differentiation-inducing factor-1 (DIF-1) is a chlorinated alkylphenone (a polyketide) found in
the cellular slime mold Dictyostelium discoideum. DIF-1 and its derivative, DIF-1 (3M) …
the cellular slime mold Dictyostelium discoideum. DIF-1 and its derivative, DIF-1 (3M) …
Exploitation of the derivatives of Dictyostelium differentiation-inducing factor-1, which promote glucose consumption in mammalian cells
Y Kubohara, H Kikuchi, Y Oshima - Life sciences, 2008 - Elsevier
AIMS: The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell
formation in the cellular slime mold Dictyostelium discoideum. DIF-1 has also been shown to …
formation in the cellular slime mold Dictyostelium discoideum. DIF-1 has also been shown to …
Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in …
Y Kubohara, Y Fukunaga, H Kikuchi, H Kuwayama - Molecules, 2023 - mdpi.com
Differentiation-inducing factor 1 (DIF-1) isolated from the cellular slime mold Dictyostelium
discoideum can inhibit mammalian calmodulin-dependent cAMP/cGMP phosphodiesterase …
discoideum can inhibit mammalian calmodulin-dependent cAMP/cGMP phosphodiesterase …
Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of …
M Arioka, F Takahashi-Yanaga, M Kubo… - Biochemical …, 2017 - Elsevier
Abstract Differentiation-inducing factor-1 (DIF-1) isolated from Dictyostelium discoideum
strongly inhibits the proliferation of various mammalian cells through the activation of …
strongly inhibits the proliferation of various mammalian cells through the activation of …
DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice
F Takahashi-Yanaga, T Yoshihara, K Jingushi… - Biochemical …, 2014 - Elsevier
We reported that differentiation-inducing factor-1 (DIF-1), synthesized by Dictyostelium
discoideum, inhibited proliferation of various tumor cell lines in vitro by suppressing the …
discoideum, inhibited proliferation of various tumor cell lines in vitro by suppressing the …
[HTML][HTML] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo
N Kubokura, F Takahashi-Yanaga, M Arioka… - Journal of …, 2015 - Elsevier
Abstract Differentiation-inducing factor-1 (DIF-1) produced by Dictyostelium discoideum
strongly inhibits the proliferation of various types of cancer cells by suppression of the Wnt/β …
strongly inhibits the proliferation of various types of cancer cells by suppression of the Wnt/β …