Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we
have demonstrated that pharmacological lowering of glycosphingolipids and subsequently …

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and
type 2 diabetes. The hyperinsulinemia that occurs as a consequence of insulin resistance is …

Previous reports have shown that glycosphingolipids can modulate the activity of the insulin
receptor, and studies in transgenic mice suggest a link between altered levels of various …

Abstract Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in
insulin signaling by regulating the association of the insulin receptor in caveolae …

Aims/hypothesis O-GlcNAcylation plays a role as a metabolic sensor regulating cellular
signalling, transcription and metabolism. Transcription factors and signalling pathways …

Obesity is associated with insulin resistance and a mild chronic inflammation in adipose
tissues. Recent studies suggested that GM3 ganglioside mediates dysfunction in insulin …

Abstract Semaglutide (GLP‐1 agonist) was approved for treating obesity. Although the
effects on weight loss and metabolism are known, the responses of adipocytes to …

The lipophilic iminosugar N-[5-(adamantan-1-ylmethoxy) pentyl]-1-deoxynojirimycin (2, AMP-
DNM) potently controls hyperglycemia in obese rodent models of insulin resistance. The …

The iminosugar N-(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-
DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes …

The molecular events of hyperglycemia-triggered increase in adipogenic induction of lipid
accumulation remain unclear. We examined the effects of hyperglycemia on adipogenic …