Chronic intermittent ethanol exposure alters behavioral flexibility in aged rats compared to adult rats and modifies protein and protein pathways related to Alzheimer's …
Repeated excessive alcohol consumption increases the risk of developing cognitive decline
and dementia. Hazardous drinking among older adults further increases such …
and dementia. Hazardous drinking among older adults further increases such …
[HTML][HTML] Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice
SM Day, SC Gironda, CW Clarke, JA Snipes… - Neurobiology of …, 2023 - Elsevier
Epidemiological studies identified alcohol use disorder (AUD) as a risk factor for Alzheimer's
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …
Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice
PE Anton, LN Rutt, ML Kaufman, N Busquet… - Brain, Behavior, and …, 2024 - Elsevier
Binge drinking is rising among aged adults (> 65 years of age), however the contribution of
alcohol misuse to neurodegenerative disease development is not well understood. Both …
alcohol misuse to neurodegenerative disease development is not well understood. Both …
Chronic alcohol exposure alters gene expression and neurodegeneration pathways in the brain of adult mice
M Liu, S Guo, D Huang, D Hu, Y Wu… - Journal of …, 2022 - content.iospress.com
Background: Chronic alcohol consumption can alter the structure of the central nervous
system and disrupt cognitive function. Alcoholics are more likely to develop …
system and disrupt cognitive function. Alcoholics are more likely to develop …
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
JL Hoffman, S Faccidomo, M Kim, SM Taylor… - International review of …, 2019 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …
most common cause of dementia in the United States. Although the link between alcohol …
[HTML][HTML] Alcohol-drinking under limited-access procedures during mature adulthood accelerates the onset of cognitive impairment in mice
CL Jimenez Chavez, E Van Doren… - Frontiers in Behavioral …, 2022 - frontiersin.org
A history of heavy drinking increases vulnerability to, and the severity of, Alzheimer's
Disease (AD) and related dementias, with Alcohol Use Disorder (AUD) identified as the …
Disease (AD) and related dementias, with Alcohol Use Disorder (AUD) identified as the …
Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Aβ (1-42) accumulation
P Marsland, AS Vore, EM DaPrano, JM Paluch… - Alcohol, 2023 - Elsevier
Chronic alcohol consumption, Alzheimer's disease (AD), and vascular dementia are all
associated with cognitive decline later in life, raising questions about whether their …
associated with cognitive decline later in life, raising questions about whether their …
[HTML][HTML] Alcohol-drinking during later life by C57BL/6J mice induces sex-and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate …
KK Szumlinski, JN Herbert, BM Espinoza… - Addiction …, 2023 - Elsevier
Heavy drinking can induce early-onset dementia and increase the likelihood of the
progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently …
progression and severity of Alzheimer's Disease and related dementias (ADRD). Recently …
[HTML][HTML] Chronic ethanol causes persistent increases in Alzheimer's tau pathology in female 3xTg-AD mice: a potential role for lysosomal impairment
AE Tucker, CM Alicea Pauneto, AM Barnett… - Frontiers in Behavioral …, 2022 - frontiersin.org
Epidemiological studies have found that heavy alcohol use is associated with increased risk
for Alzheimer's disease (AD)(Schwarzinger et al., 2018), with frequent drinking earlier in …
for Alzheimer's disease (AD)(Schwarzinger et al., 2018), with frequent drinking earlier in …
Animal models for studies of alcohol effects on the trajectory of age-related cognitive decline
TC Foster - Alcohol, 2023 - Elsevier
There is growing interest in understanding how ethanol use interacts with advancing age to
influence the brain and cognition. Animal models are employed to investigate the cellular …
influence the brain and cognition. Animal models are employed to investigate the cellular …