Simple Summary TGFβ and TIM-3 have been implicated in driving immune evasion and
poor response to anti-PD-1/PD-L1 immune checkpoint inhibitors (ICIs). Using large-scale …

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key
players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the …

ABSTRACT T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, shows therapeutic
potential. However, the molecular mechanism by which Tim-3 regulates immune responses …

T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an inhibitory immune
checkpoint, which suppresses anti-tumor immune responses. TIM-3 expression on different …

Simple Summary Since TIM-3 on T cells or dendritic cells (DCs) has recently emerged as an
attractive target for immunotherapy, we examined its expression on DCs using …

Background T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a vital
immune checkpoint that regulates the immune response. However, the specific role of TIM3 …

T-cell exhaustion represents a progressive loss of T-cell function. The inhibitory receptor PD-
1 is known to negatively regulate CD8+ T cell responses directed against tumor antigen, but …

The spatial organization of immune cells within the tumor microenvironment (TME) largely
determines the anti-tumor immunity and also highly predicts tumor progression and …

The blockade of immune checkpoint receptors has made great strides in the treatment of
major cancers, including melanoma, Hodgkin's lymphoma, renal, and lung cancer. However …

T cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) is an immune
checkpoint molecule and a target for anti-cancer therapy. In this study, we examined …