Transcription termination at mRNA genes is linked to polyadenylation. Cleavage at the poly
(A) site generates an entry point for the Rat1/Xrn2 exonuclease, which degrades the …

Transcription termination by RNA polymerase II is coupled to transcript 3′ end formation. A
large cleavage and polyadenylation complex containing the major poly (A) polymerase …

Most eukaryotic genes are transcribed by RNA polymerase II (Pol II), including those that
produce mRNAs and many noncoding functional RNAs. Proper expression of these genes …

RNA polymerase II (Pol II) termination is triggered by sequences present in the nascent
transcript. Termination of pre-mRNA transcription is coupled to recognition of cis-acting …

RNA polymerase II transcribes both coding and noncoding genes, and termination of these
different classes of transcripts is facilitated by different sets of termination factors. Pre …

Glc7, the yeast protein phosphatase 1, is a component of the cleavage and polyadenylation
factor (CPF). Here we show that downregulation of Glc7, or its dissociation from CPF in the …

Eukaryotic RNA polymerase II transcribes precursors of mRNAs and of non‐protein‐coding
RNAs such as snRNAs and snoRNAs. These RNAs have to be processed at their 3′ ends …

RNA polymerase II transcribes genes encoding proteins and a large number of small stable
RNAs. While pre‐mRNA 3′‐end formation requires a machinery ensuring tight coupling …

Termination of transcription by RNA polymerase II (Pol II) is a poorly understood yet
essential step in eukaryotic gene expression. Termination of pre-mRNA synthesis is coupled …

RNA polymerase II synthesizes a diverse set of transcripts including both protein-coding and
non-coding RNAs. One major difference between these two classes of transcripts is the …