The FADS1 rs174550 Genotype Modifies the n‐3 and n‐6 PUFA and Lipid Mediator Responses to a High Alpha‐Linolenic Acid and High Linoleic Acid Diets
T Meuronen, MA Lankinen, J Kolmert… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope The fatty acid composition of plasma lipids, which is associated with biomarkers and
risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids …
risk of non‐communicable diseases, is regulated by dietary polyunsaturated fatty acids …
Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits
J Dumont, L Goumidi, B Grenier-Boley, D Cottel… - Clinical Nutrition, 2018 - Elsevier
Background & aims Blood levels of polyunsaturated fatty acids (PUFAs) are under control of
endogenous synthesis via Δ5-and Δ6-desaturases, encoded by the FADS1 and FADS2 …
endogenous synthesis via Δ5-and Δ6-desaturases, encoded by the FADS1 and FADS2 …
[HTML][HTML] Dietary n− 3 and n− 6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the …
Y Lu, EJM Feskens, MET Dollé, S Imholz… - The American journal of …, 2010 - Elsevier
Background: The δ-5 and δ-6 desaturases, encoded by the FADS1 and FADS2 genes, are
rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide …
rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide …
[HTML][HTML] FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study
T Meuronen, MA Lankinen, O Kärkkäinen… - European Journal of …, 2022 - Springer
Introduction Fatty acid desaturase 1 (FADS1) gene encodes for delta-5 desaturase enzyme
which is needed in conversion of linoleic acid (LA) to arachidonic acid (AA). Recent studies …
which is needed in conversion of linoleic acid (LA) to arachidonic acid (AA). Recent studies …
[HTML][HTML] Inflammatory response to dietary linoleic acid depends on FADS1 genotype
MA Lankinen, A Fauland, B Shimizu, J Ågren… - The American journal of …, 2019 - Elsevier
Background The health benefits of substituting dietary polyunsaturated fatty acids (PUFAs)
for saturated fatty acids are well known. However, limited information exists on how the …
for saturated fatty acids are well known. However, limited information exists on how the …
FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health
B Koletzko, E Reischl, C Tanjung… - Annual review of …, 2019 - annualreviews.org
Variants in the FADS gene cluster modify the activity of polyunsaturated fatty acid (PUFA)
desaturation and the lipid composition in human blood and tissue. FADS variants have been …
desaturation and the lipid composition in human blood and tissue. FADS variants have been …
The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults
CM O'Neill, AM Minihane - Proceedings of the Nutrition Society, 2017 - cambridge.org
The aim of this review was to determine the impact of the fatty acid desaturase (FADS)
genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including …
genotype on plasma and tissue concentrations of the long-chain (LC) n-3 PUFA, including …
Identification of a functional FADS1 3′ UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels
X Hermant, C Delay, A Flaig, J Luque-Bedregal… - Journal of clinical …, 2018 - Elsevier
Background Blood polyunsaturated fatty acid (PUFA) levels are determined by diet and by
endogenous synthesis via Δ5-and Δ6-desaturases (encoded by the FADS1 and FADS2 …
endogenous synthesis via Δ5-and Δ6-desaturases (encoded by the FADS1 and FADS2 …
The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha‐linolenic Acid Containing Plant Oils–Genotype Based Randomized Trial …
MA Lankinen, VD de Mello, T Meuronen… - Molecular Nutrition & …, 2021 - Wiley Online Library
Scope The article investigates the FADS1 rs174550 genotype interaction with dietary
intakes of high linoleic acid (LA) and high alpha‐linolenic acid (ALA) on the response of fatty …
intakes of high linoleic acid (LA) and high alpha‐linolenic acid (ALA) on the response of fatty …
Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism
C Glaser, J Heinrich, B Koletzko - Metabolism, 2010 - Elsevier
Tissue availability of polyunsaturated fatty acids (PUFAs) depends on dietary intake and
metabolic turnover and has a major impact on human health. Strong associations between …
metabolic turnover and has a major impact on human health. Strong associations between …