Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1

A Morita, Y Iwasaki, K Kobata, T Iida, T Higashi, K Oda… - Life sciences, 2006 - Elsevier
Analogs of capsaicin, such as capsaicinoids and capsinoids, activate a cation channel,
transient receptor potential cation channel vanilloid subfamily 1 (TRPV1), and then increase …

Transient receptor potential vanilloid 1 (TRPV1)‐independent actions of capsaicin on cellular excitability and ion transport

M Oz, DE Lorke, FC Howarth - Medicinal Research Reviews, 2023 - Wiley Online Library
Capsaicin is a naturally occurring alkaloid derived from chili pepper that is responsible for its
hot pungent taste. Capsaicin is known to exert multiple pharmacological actions, including …

Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities

LGB Ferreira, JV Faria, JPS Dos Santos… - European Journal of …, 2020 - Elsevier
Capsaicin (CAP) is a spice-derived substance of the genus Capsicum, which has high
pungency and therapeutic potential. For many years, it has been considered only as an …

Activation of transient receptor potential A1 by a non‐pungent capsaicin‐like compound, capsiate

K Shintaku, K Uchida, Y Suzuki, Y Zhou… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Capsiate is produced by 'CH‐19 Sweet'(Capsicum annuun
L.), a non‐pungent cultivar of red pepper. Like capsaicin, capsiate is thought to enhance …

Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons

Y Takayama, D Uta, H Furue… - Proceedings of the …, 2015 - National Acad Sciences
The capsaicin receptor transient receptor potential cation channel vanilloid 1 (TRPV1) is
activated by various noxious stimuli, and the stimuli are converted into electrical signals in …

Acidification of rat TRPV1 alters the kinetics of capsaicin responses

TR Neelands, MF Jarvis, P Han, CR Faltynek… - Molecular …, 2005 - journals.sagepub.com
TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as
capsaicin, as well as by acidic conditions and temperatures above 42° C. These activators …

Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel

I Nagy, D Friston, JS Valente, JVT Perez… - Capsaicin as a …, 2014 - Springer
The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1),
has been identified as a polymodal transducer molecule on a sub-set of primary sensory …

[HTML][HTML] A single TRPV1 amino acid controls species sensitivity to capsaicin

Y Chu, BE Cohen, H Chuang - Scientific reports, 2020 - nature.com
Chili peppers produce capsaicin (a vanilloid) that activates the transient receptor potential
cation channel subfamily V member 1 (TRPV1) on sensory neurons to alter their membrane …

Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel

W Long, M Fatehi, S Soni, R Panigrahi… - The Journal of …, 2020 - Wiley Online Library
Key points 25‐Hydroxyvitamin D (25OHD) is a partial agonist of TRPV1 whereby 25OHD
can weakly activate TRPV1 yet antagonize the stimulatory effects of the full TRPV1 agonists …

Vanilloid receptor TRPV1 is not activated by vanilloids applied intracellularly

L Vyklický, A Lyfenko, DP Kuffler, V Vlachová - Neuroreport, 2003 - journals.lww.com
The vanilloid receptor TRPV1 is a ligand-gated cation channel that can be activated by
capsaicin, acids and noxious heat. For vanilloids, a stretch of 8 amino acids in the vicinity of …