The RNA transcriptome varies in response to cellular differentiation as well as
environmental factors, and can be characterized by the diversity and abundance of transcript …

Alternative splicing is a major contributor to cellular diversity. Therefore the identification and
quantification of differentially spliced transcripts in genome-wide transcript analysis is an …

Over the last few years, RNA-seq has been used to study alterations in alternative splicing
related to several diseases. Bioinformatics workflows used to perform these studies can be …

Recent study revealed that most human genes have alternative splicing and can produce
multiple isoforms of transcripts. Differences in the relative abundance of the isoforms of a …

RNA alternative splicing, a post-transcriptional stage in eukaryotes, is crucial in cellular
homeostasis and disease processes. Due to the rapid development of the next-generation …

Motivation: In eukaryotic cells, alternative splicing expands the diversity of RNA transcripts
and plays an important role in tissue-specific differentiation, and can be misregulated in …

Differential splicing (DS) is a post-transcriptional biological process with critical, wide-
ranging effects on a plethora of cellular activities and disease processes. To date, a number …

Motivation: Alternative splicing is central for cellular processes and substantially increases
transcriptome and proteome diversity. Aberrant splicing events often have pathological …

Background While the reconstruction of transcripts from a sample of RNA-Seq data is a
computationally expensive and complicated task, the detection of splicing events from RNA …

Although RNA-Seq data provide unprecedented isoform-level expression information,
detection of alternative isoform regulation (AIR) remains difficult, particularly when working …