Background Many depressed patients do not achieve response or remission despite
adequate treatment. Identifying predictors of outcome can contribute to developing …

Background Treatment resistant depression (TRD) poses a significant clinical challenge,
despite a range of efficacious specialist treatments. Accurately predicting response a priori …

Objective: To assess a representative sample of clinically depressed outpatients during
acute treatment with antidepressant medication monotherapy to determine clinical outcomes …

BACKGROUND: Delayed onset of efficacy of antidepressants and a high proportion of
depressed patients being poor or non-responders to antidepressants are well known clinical …

Background Although research shows that more depressed patients respond to combined
antidepressants (ADM) and psychotherapy than either alone, many patients do not respond …

Background Depression causes significant morbidity, which impacts mental health, overall
general health outcomes, everyday functioning and quality of life. This study aims to …

Background Limited controlled data exist to guide treatment choices for clinicians caring for
patients with major depressive disorder (MDD). Although many putative predictors of …

Introduction: Assessment of depression severity is of key importance, since several clinical
guidelines recommend choice of treatment dependent on the depression severity grade …

Depression in psychiatric samples has been found to be more severe with greater functional
impairment than depression in primary care settings [Schwenk et al., 1996]. However …

Background Remission is a common outcome of short-term trials and the main goal of acute
and longterm treatment. The longitudinal stability of remission has rarely been investigated …