Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1‐13C]pyruvate magnetic resonance spectroscopy
Purpose Hyperpolarized [1‐13C] pyruvate MRS can measure cardiac metabolism in vivo.
We investigated whether [1‐13C] pyruvate MRS could predict left ventricular remodeling …
We investigated whether [1‐13C] pyruvate MRS could predict left ventricular remodeling …
Hyperpolarized 13C magnetic resonance reveals early‐ and late‐onset changes to in vivo pyruvate metabolism in the failing heart
Aims Impaired energy metabolism has been implicated in the pathogenesis of heart failure.
Hyperpolarized 13C magnetic resonance (MR), in which 13C‐labelled metabolites are …
Hyperpolarized 13C magnetic resonance (MR), in which 13C‐labelled metabolites are …
Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2‐13C]pyruvate MRS
Introduction The healthy heart has remarkable metabolic flexibility that permits rapid
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …
switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP …
[HTML][HTML] Real time measurement of myocardial substrate selection in vivo using hyperpolarized 13C magnetic resonance
Background Cardiac dysfunction is often associated with a shift in substrate preference and
metabolism, but current in vivo techniques only provide information on substrate uptake …
metabolism, but current in vivo techniques only provide information on substrate uptake …
Acute hypertensive stress imaged by cardiac hyperpolarized [1‐13C]pyruvate magnetic resonance
Purpose Deranged metabolism is now recognized as a key causal factor in a variety of heart
diseases, and is being studied extensively. However, invasive methods may alter …
diseases, and is being studied extensively. However, invasive methods may alter …
Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience
Rationale: Altered cardiac energetics is known to play an important role in the progression
toward heart failure. A noninvasive method for imaging metabolic markers that could be …
toward heart failure. A noninvasive method for imaging metabolic markers that could be …
Hyperpolarized 13C NMR detects rapid drug‐induced changes in cardiac metabolism
C Khemtong, NR Carpenter, LL Lumata… - Magnetic resonance …, 2015 - Wiley Online Library
Purpose The diseased myocardium lacks metabolic flexibility and responds to stimuli
differently compared with healthy hearts. Here, we report the use of hyperpolarized 13C …
differently compared with healthy hearts. Here, we report the use of hyperpolarized 13C …
[HTML][HTML] Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge
Background The heart has metabolic flexibility, which is influenced by fed/fasting states, and
pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM) …
pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM) …
Imaging regional metabolic changes in the ischemic rat heart in vivo using hyperpolarized [1-13C] pyruvate
MH Lauritzen, P Magnusson, C Laustsen, SA Butt… - Tomography, 2017 - mdpi.com
We evaluated the use of hyperpolarized 13 C magnetic resonance imaging (MRI) in an open-
chest rat model of myocardial infarction to image regional changes in myocardial …
chest rat model of myocardial infarction to image regional changes in myocardial …
Reproducibility study for free‐breathing measurements of pyruvate metabolism using hyperpolarized 13C in the heart
Spatially resolved images of hyperpolarized 13C substrates and their downstream products
provide insight into real‐time metabolic processes occurring in vivo. Recently …
provide insight into real‐time metabolic processes occurring in vivo. Recently …