Stepping down triple therapy in COPD

I Small, M Reilly, J Roberts - 2014 - pcrs-uk.org
Although there is a strong evidence base for pharmacotherapy in COPD, much of this is
based on the use of individual therapies such as long acting bronchodilators (LABA/LAMA) …

Triple therapy for the management of COPD: a review

K Gaebel, RA McIvor, F Xie, G Blackhouse… - COPD: Journal of …, 2011 - Taylor & Francis
Triple therapy for COPD consists of a long-acting anti-cholinergic bronchodilator, a long-
acting beta-agonist bronchodilator, and an inhaled corticosteroid. Guidelines from the …

Safety considerations with dual bronchodilator therapy in COPD: an update

MG Matera, P Rogliani, L Calzetta, M Cazzola - Drug safety, 2016 - Springer
Combining a long-acting β 2-agonist (LABA) with a long-acting anti-muscarinic agent
(LAMA) provides synergistic benefit on airway smooth muscle relaxation, which may have …

Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD

P Kardos, S Worsley, D Singh… - … journal of chronic …, 2016 - Taylor & Francis
Long-acting muscarinic antagonist (LAMA) or long-acting β2-agonist (LABA) bronchodilators
and their combination are recommended for the maintenance treatment of chronic …

Characterization of Patients with Chronic Obstructive Pulmonary Disease Initiating Single-Inhaler Long-Acting Muscarinic Antagonist/Long-Acting β2-Agonist Dual …

G Requena, V Banks, A Czira, R Wood… - … Journal of Chronic …, 2022 - Taylor & Francis
Purpose Treatment pathways of patients with chronic obstructive pulmonary disease
(COPD) receiving single-inhaler dual therapies remain unclear. We aimed to describe …

Impact of ICS/LABA and LABA/LAMA FDCs on functional and clinical outcomes in COPD: a network meta-analysis

L Calzetta, F Di Marco, F Blasi, M Cazzola… - Pulmonary …, 2019 - Elsevier
Background Inhaled corticosteroid (ICS)/long-acting β 2 agonist (LABA) fixed-dose
combinations (FDCs) and LABA/long-acting muscarinic antagonist (LAMA) FDCs are …

[HTML][HTML] Comparing the efficacy and safety profile of triple fixed-dose combinations in COPD: a meta-analysis and IBiS score

P Rogliani, J Ora, F Cavalli, M Cazzola… - Journal of clinical …, 2022 - mdpi.com
Background: Triple fixed-dose combination (FDC) therapy is recommended in severe
chronic obstructive pulmonary disease (COPD) patients experiencing frequent …

Comparative effects of LAMA-LABA-ICS vs LAMA-LABA for COPD: cohort study in real-world clinical practice

S Suissa, S Dell'Aniello, P Ernst - Chest, 2020 - Elsevier
Background Triple therapy combinations of a long-acting muscarinic antagonist (LAMA), a
long-acting beta 2-agonist (LABA), and an inhaled corticosteroid (ICS) for COPD were …

[HTML][HTML] The impact of 52-week single inhaler device triple therapy versus dual therapy on the mortality of COPD patients: a systematic review and meta-analysis of …

CC Lai, CH Chen, KH Chen, CY Wang, TM Huang… - Life, 2022 - mdpi.com
There are more single inhaler device triple therapy available for COPD patients now.
However, the effect of long-term triple therapy fixed dose combination (FDC) on mortality …

Comment on: Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review …

P Almagro, P Martinez-Camblor - European Respiratory …, 2023 - Eur Respiratory Soc
We read with great interest the meta-analysis recently published in the European
Respiratory Journal by Yang et al.[1] concerning the risk of major adverse cardiovascular …