Elevated alternative colony stimulating factor 3 receptor (CSF3R) isoforms are observed in
myelodysplastic syndromes (MDS) and other myeloid neoplasms, but their role in driving …

Alternatively spliced colony stimulating factor 3 receptor (CSF3R) isoforms Class III and
Class IV are observed in myelodysplastic syndromes (MDS), but their roles in disease …

Background. Myelodysplastic syndromes (MDS) constitute the most common group of bone
marrow failure disorders, characterized by ineffective hematopoiesis and a significant risk of …

Spliceosomal mutations account for the most frequent class of mutations in patients with
MDS and CMML, yet the mechanism by which these mutations perform their driver function …

Myelodysplastic syndromes (MDS) are a group of neoplasms characterized by ineffective
myeloid hematopoiesis and various risks for leukemia. SRSF2, a member of the …

Splicing factor mutations are characteristic of myelodysplastic syndromes (MDS) and related
myeloid neoplasms and implicated in their pathogenesis, but their roles in the development …

The granulocyte colony stimulating factor receptor (CSF3R) is a critical regulator of
neutrophil production with multiple alternatively spliced variants. The truncated CSF3R-V4 …

Serine/arginine-rich splicing factor 2 (SRSF2) is a member of the SR protein family that is
involved in both constitutive and alternative mRNA splicing. Mutations in SRSF2 gene are …

Abstract Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is
the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with …

Recurrent mutations in the splicing factor SRSF2 are associated with poor clinical outcomes
in myelodysplastic syndromes (MDS). Their high frequency suggests these mutations drive …