Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …

Metformin is the most commonly prescribed medication for type 2 diabetes, owing to its
glucose-lowering effects, which are mediated through the suppression of hepatic glucose …

Metformin is a blood-glucose-lowering medication with physiological effects that extend
beyond its anti-diabetic indication. Recently, it was reported that metformin lowers body …

Abstract Growth differentiation factor 15 (GDF15), a distant member of the transforming
growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa dimer. In …

Abstract Growth/differentiation factor 15 (GDF15), also known as MIC-1, is a distant member
of the transforming growth factor-β (TGF-β) superfamily and has been implicated in various …

Abstract Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent
member of the TGF-β superfamily and is associated with body-weight regulation in humans …

Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

Growing evidence supports that pharmacological application of growth differentiation factor
15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via …