Diabetic retinopathy is a multifactorial microvascular complication, and its pathogenesis
hasn't been fully elucidated. The irreversible oxidation of cysteine 674 (C674) in the …

PURPOSE. Sarco/Endoplasmic Reticulum Ca 2+-ATPase (SER-CAs) isoforms, SERCA2b
(100Kd) and SERCA3 (97Kd), are co-expressed in some non-muscle tissues. Both types of …

Background SERPINA3K, an extracellular serine proteinase inhibitor (serpin), has been
shown to have decreased levels in the retinas of diabetic rats, which may contribute to …

This study tested the hypothesis that diabetes promotes a greater than normal cytosolic
calcium level in rod cells that activates a Ca 2+-sensitive protease, calpain, resulting in …

Maintenance of cellular calcium levels is critical to cell function. Loss of calcium homeostasis
might be a contributing factor to the development of cataract in the lens. In lens epithelium …

The sarcoplasmic–endoplasmic reticulum calcium ATPase (SERCA) is a key intracellular
calcium transporter, which regulates cellular calcium concentration [Ca2+] by transporting …

Purpose The purpose of this study was to evaluate caspase-14 expression in the retina
under normal and diabetic conditions, and to determine whether caspase-14 contributes to …

Background and aim Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is
critical in maintaining Ca 2+ homeostasis. The cysteine 674 (C674) is the key redox …

We recently showed that caspase‐14 is a novel molecule in retina with potential role in
accelerated vascular cell death during diabetic retinopathy (DR). Here, we evaluated …

Apoptosis of retinal endothelial cells and pericytes is postulated to contribute to the
development of retinopathy in diabetes. The goal of this study is to investigate diabetes …