Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour
EG Mills, C Izzi-Engbeaya, A Abbara… - Nature Reviews …, 2021 - nature.com
The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …
their pathophysiological roles are increasingly the subject of investigation. Evidence …
[PDF][PDF] Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women
PA Kołodziejski, E Pruszyńska-Oszmałek… - Physiological …, 2018 - biomed.cas.cz
Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …
of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum …
Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III
The novel neuropeptide spexin (SPX) was discovered using bioinformatics. The function of
this peptide is currently under investigation. Here, we identified SPX along with a second …
this peptide is currently under investigation. Here, we identified SPX along with a second …
[HTML][HTML] The emerging role (s) for kisspeptin in metabolism in mammals
A Wolfe, MA Hussain - Frontiers in Endocrinology, 2018 - frontiersin.org
Kisspeptin was initially identified as a metastasis suppressor. Shortly after the initial
discovery, a key physiologic role for kisspeptin emerged in the regulation of fertility, with …
discovery, a key physiologic role for kisspeptin emerged in the regulation of fertility, with …
The effects of kisspeptin on β‐cell function, serum metabolites and appetite in humans
C Izzi‐Engbeaya, AN Comninos… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aims To investigate the effect of kisspeptin on glucose‐stimulated insulin secretion and
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …
appetite in humans. Materials and methods In 15 healthy men (age: 25.2±1.1 years; BMI …
[HTML][HTML] Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice
A Reyes-Alcaraz, YN Lee, GH Son, NH Kim, DK Kim… - Scientific reports, 2016 - nature.com
The novel neuropeptide spexin (SPX) was discovered to activate galanin receptor 2
(GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to …
(GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to …
[HTML][HTML] Kisspeptin and metabolism: the brain and beyond
Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive
functions, recent data described its action in the control of metabolism. Of particular interest …
functions, recent data described its action in the control of metabolism. Of particular interest …
[HTML][HTML] The role of kisspeptin neurons in reproduction and metabolism
CJL Harter, GS Kavanagh… - Journal of …, 2018 - joe.bioscientifica.com
Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …
There is kisspeptin–and then there is kisspeptin
MA Hussain, WJ Song, A Wolfe - Trends in Endocrinology & Metabolism, 2015 - cell.com
While kisspeptin was initially found to function as a metastasis suppressor, after
identification of its receptor KISS1R and their expression profiles in tissues such as the …
identification of its receptor KISS1R and their expression profiles in tissues such as the …
Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat
S Forbes, XF Li, J Kinsey-Jones, K O'Byrne - Neuroscience letters, 2009 - Elsevier
The orexigenic gut peptide ghrelin negatively modulates the hypothalamic–pituitary–
gonadal (HPG) axis. Hyperghrelinaemia results during negative energy balance, a state …
gonadal (HPG) axis. Hyperghrelinaemia results during negative energy balance, a state …