The status of the neuroendocrine reproductive axis differs dramatically during various stages
of development, and also differs in several critical ways between the sexes, including its …

Aims/hypothesis Kisspeptin is a novel peptide identified as an endogenous ligand of the G-
protein-coupled receptor 54 (GPR-54), which plays a crucial role in puberty and …

Hypogonadotropism is a common feature of uncontrolled diabetes, for which the ultimate
mechanism remains to be elucidated. Kisspeptins, ligands of G protein–coupled receptor 54 …

The Kiss1 gene encodes a family of peptides called kisspeptins, which are the natural
ligands for the receptor GPR54. In humans and mice, inactivating mutations of GPR54 …

It is well established that reproductive function is metabolically gated. However, the
mechanisms whereby energy stores and metabolic cues influence fertility are yet to be …

Kisspeptins, products of the KiSS-1 gene with ability to bind G protein-coupled receptor 54
(GPR54), have been recently identified as major gatekeepers of reproductive function with …

Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of
reproductive functions in mammals owing to its involvement in the direct activation of …

Hypothalamic peptidergic neurons using kisspeptin (KP) and its co-transmitters for
communication are critically involved in the regulation of mammalian reproduction and …

Kisspeptin has recently been identified as a key neuroendocrine gatekeeper of reproduction
and is essential for the initiation of human puberty and maintenance of adult reproduction …

GnRH neurons play a pivotal role in the central regulation of fertility. Kisspeptin greatly
increases GnRH/LH release and GnRH neuron firing activity and may be involved in …