Membrane interactivity of capsaicin antagonized by capsazepine
M Mizogami, H Tsuchiya - International Journal of Molecular Sciences, 2022 - mdpi.com
Although the pharmacological activity of capsaicin has been explained by its specific
binding to transient receptor potential vanilloid type 1, the amphiphilic structure of capsaicin …
binding to transient receptor potential vanilloid type 1, the amphiphilic structure of capsaicin …
Effects of capsaicin on biomimetic membranes
N Sharma, HTT Phan, T Yoda, N Shimokawa… - Biomimetics, 2019 - mdpi.com
Capsaicin is a natural compound that produces a warm sensation and is known for its
remarkable medicinal properties. Understanding the interaction between capsaicin with lipid …
remarkable medicinal properties. Understanding the interaction between capsaicin with lipid …
Biphasic membrane effects of capsaicin, an active component in Capsicum species
H Tsuchiya - Journal of Ethnopharmacology, 2001 - Elsevier
Capsaicin, an active component in Capsicum species, not only stimulates sensory afferent
neurons but also inhibits bacterial growth and platelet aggregation. To address the …
neurons but also inhibits bacterial growth and platelet aggregation. To address the …
Capsaicin Fluidifies the Membrane and Localizes Itself near the Lipid–Water Interface
A Torrecillas, M Schneider… - ACS Chemical …, 2015 - ACS Publications
Capsaicin is the chemical responsible for making some peppers spicy hot, but additionally it
is used as a pharmaceutical to alleviate different pain conditions. Capsaicin binds to the …
is used as a pharmaceutical to alleviate different pain conditions. Capsaicin binds to the …
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity
JA Lundbaek, P Birn, SE Tape, GES Toombes… - Molecular …, 2005 - ASPET
At submicromolar concentrations, capsaicin specifically activates the TRPV1 receptor
involved in nociception. At micro-to millimolar concentrations, commonly used in clinical and …
involved in nociception. At micro-to millimolar concentrations, commonly used in clinical and …
Capsaicin effects on non-neuronal plasma membranes
JB Meddings, CM Hogaboam, K Tran… - Biochimica et biophysica …, 1991 - Elsevier
Capsaicin has been touted as a pharmacological tool specific for sensory afferent neurons
and is widely used in neurophysiological studies. However, we have recently demonstrated …
and is widely used in neurophysiological studies. However, we have recently demonstrated …
Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel
J Jung, SW Hwang, J Kwak, SY Lee… - Journal of …, 1999 - Soc Neuroscience
Capsaicin (CAP) excites small sensory neurons, causing pain, neurogenic inflammation,
and other visceral reflexes. These effects have been proposed to be the result of CAP …
and other visceral reflexes. These effects have been proposed to be the result of CAP …
Location, partitioning behavior, and interaction of capsaicin with lipid bilayer membrane: Study using its intrinsic fluorescence
J Swain, A Kumar Mishra - The Journal of Physical Chemistry B, 2015 - ACS Publications
Capsaicin is an ingredient of a wide variety of red peppers, and it has various
pharmacological and biological applications. The present study explores the interaction of …
pharmacological and biological applications. The present study explores the interaction of …
Capsaicin and its analogs induce ion channels in planar lipid bilayers
AM Feigin, EV Aronov, BP Bryant, JH Teeter… - …, 1995 - journals.lww.com
THE irritating, pungent compound, capsaicin (10–20$ mUM), induces the formation of non-
selective ion channels with a wide variety of conductances in protein-free lipid bilayers …
selective ion channels with a wide variety of conductances in protein-free lipid bilayers …
Capsaicin affects the structure and phase organization of phospholipid membranes
FJ Aranda, J Villalaín, JC Gómez-Fernández - Biochimica et Biophysica …, 1995 - Elsevier
Capsaicin is a natural compound with pharmacological and toxicological effects, which
given its hydrophobicity, can influence the structure of membranes. The interaction of …
given its hydrophobicity, can influence the structure of membranes. The interaction of …