In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

The dietary compound capsaicin is responsible for the “hot and spicy” taste of chili peppers
and pepper extracts. It is a valuable pharmacological agent with several therapeutic …

Analogs of capsaicin, such as capsaicinoids and capsinoids, activate a cation channel,
transient receptor potential cation channel vanilloid subfamily 1 (TRPV1), and then increase …

LETTERS conditions, elicits one of the described sensory-efferent responses9, 10 of
capsaicin-sensitive afferents. Regarding the interesting point of an interaction between VR1 …

Capsaicin bestows spiciness by activating TRPV1 channel with exquisite potency and
selectivity. Although a capsaicin-bound channel structure was previously resolved by cryo …

Vyklický, Ladislav, Helena Knotková-Urbancová, Zdeňka Vitásková, Viktorie Vlachová,
Michaela Kress, and Peter W. Reeh. Inflammatory mediators at acidic pH activate capsaicin …

Capsaicin binds to a specific recognition site, referred to as the vanilloid receptor, which it
shares with the natural, ultrapotent agonist resiniferatoxin and with the competitive …

Birds are indifferent to the pain‐producing effects of capsaicin. However, avian primary
sensory neurons exhibit heat‐evoked membrane currents resembling those carried by …

Capsaicin (Cap) and its analogs (CAPanalogs) have diverse effects in sensory neurons
including analgesia, implying they modulate other cellular targets besides the TRPV1 Cap …