A role for pericytes in coronary no-reflow
FM O'farrell, D Attwell - Nature reviews cardiology, 2014 - nature.com
Despite efforts to restore tissue perfusion after myocardial infarction, coronary no-reflow—a
failure to achieve adequate reperfusion of the cardiac microcirculation—is a common …
failure to achieve adequate reperfusion of the cardiac microcirculation—is a common …
Capillary pericytes mediate coronary no-reflow after myocardial ischaemia
After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often
occurs even after flow is restored in an upstream artery. This' no-reflow'phenomenon …
occurs even after flow is restored in an upstream artery. This' no-reflow'phenomenon …
Mechanisms of the “no-reflow” phenomenon after acute myocardial infarction: Potential role of pericytes
Pericytes contract during myocardial ischemia resulting in capillary constriction and no
reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size …
reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size …
Pericytes constrict blood vessels after myocardial ischemia
MA Costa, AE Paiva, JP Andreotti, MV Cardoso… - Journal of molecular and …, 2018 - Elsevier
No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If
prolonged it leads to profound damages in the myocardium. The lack of a detailed …
prolonged it leads to profound damages in the myocardium. The lack of a detailed …
Mechanism and potential treatment of the “no reflow” phenomenon after acute myocardial infarction: role of pericytes and GPR39
C Methner, Z Cao, A Mishra… - American Journal of …, 2021 - journals.physiology.org
The “no reflow” phenomenon, where the coronary artery is patent after treatment of acute
myocardial infarction (AMI) but tissue perfusion is not restored, is associated with worse …
myocardial infarction (AMI) but tissue perfusion is not restored, is associated with worse …
Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo
JJ Shrouder, GM Calandra, S Filser, DP Varga… - Brain, 2024 - academic.oup.com
Incomplete reperfusion of the microvasculature ('no-reflow') after ischaemic stroke damages
salvageable brain tissue. Previous ex vivo studies suggest pericytes are vulnerable to …
salvageable brain tissue. Previous ex vivo studies suggest pericytes are vulnerable to …
No-reflow phenomenon: maintaining vascular integrity
RA Kloner - Journal of cardiovascular pharmacology and …, 2011 - journals.sagepub.com
The no-reflow phenomenon relates to the inability to reperfuse regions of the myocardium
after ischemia, despite removal of the large epicardial coronary artery occlusion. The …
after ischemia, despite removal of the large epicardial coronary artery occlusion. The …
No-reflow: again prevention is better than treatment
G Niccoli, RK Kharbanda, F Crea… - European heart …, 2010 - academic.oup.com
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion strategy for
treating acute ST-segment elevation myocardial infarction (STEMI). The main goals are to …
treating acute ST-segment elevation myocardial infarction (STEMI). The main goals are to …
No-reflow phenomenon in the heart and brain
The no-reflow phenomenon refers to the observation that when an organ is made ischemic
by occlusion of a large artery supplying it, restoration of patency in that artery does not …
by occlusion of a large artery supplying it, restoration of patency in that artery does not …
Pericyte constriction after stroke: the jury is still out
We are writing in response to the paper by Yemisci et al. 1. The authors propose that
ischemia-reperfusion causes widespread, long-lasting dynamic constriction of pericytes …
ischemia-reperfusion causes widespread, long-lasting dynamic constriction of pericytes …