Background Both fosinopril and valsartan are effective in protecting endothelial function. We
hypothesized that they may also reduce myocardial no-reflow. In addition, suppression of …

Treatment of acute cardiac ischemia focuses on reestablishment of blood flow in coronary
arteries. However, impaired microvascular perfusion damages peri-infarct tissue, despite …

In patients with acute myocardial infarction (MI), coronary microvasculatures are often
damaged irreversibly due to myocardial ischemia and reperfusion, and flow to the previously …

No-reflow phenomenon, defined as inadequate perfusion of myocardium without evident
artery obstruction, occurs at a high incidence after coronary revascularization. The …

Increases in neuronal activity cause an enhanced blood flow to the active brain area. This
neurovascular coupling is regulated by multiple mechanisms: Adenosine and lactate …

Mural cells known as pericytes envelop the endothelial layer of microvessels throughout the
body and have been described to have tissue-specific functions. Cardiac pericytes are …

Microvascular obstruction (MO), or no-reflow phenomenon, defines an area within an acute
myocardial infarction (MI) that had undergone not only myocyte necrosis but also severe and …

Pericytes are functional components of the neurovascular unit (NVU). They provide support
to other NVU components and maintain normal physiological functions of the blood-brain …

Pericytes are critical yet understudied cells that are a central component of the
neurovascular unit. They are connected to the cerebrovascular endothelium and help …

Primary percutaneous angioplasty (pPCI), represents the reperfusion strategy of choice for
patients with STEMI according to current international guidelines of the European Society of …