CUB and Sushi Multiple Domains 1 (CSMD1) opposes the complement cascade in neural tissues
Schizophrenia risk is associated with increased gene copy number and brain expression of
complement component 4 (C4). Because the complement system facilitates synaptic …
complement component 4 (C4). Because the complement system facilitates synaptic …
[HTML][HTML] CSMD1 regulates brain complement activity and circuit development
Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …
neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 …
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia
The most significant common variant association for schizophrenia (SCZ) reflects increased
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
expression of the complement component 4A (C4A). Yet, it remains unclear how C4A …
[HTML][HTML] Neuropsychological Deficits in Mice Depleted of the Schizophrenia Susceptibility Gene CSMD1
Recent meta-analyses of schizophrenia genome-wide association studies (GWASs) have
identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong …
identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong …
[HTML][HTML] Lower complement C1q levels in first-episode psychosis and in schizophrenia
M Koskuvi, S Malwade, JG Lekander, E Hörbeck… - Brain, behavior, and …, 2024 - Elsevier
Recent evidence has implicated complement component (C) 4A in excessive elimination of
synapses in schizophrenia. C4A is believed to contribute to physiological synapse removal …
synapses in schizophrenia. C4A is believed to contribute to physiological synapse removal …
The complement system in schizophrenia: where are we now and what's next?
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …
pathogens and removal of waste materials. Recent evidence has implicated the complement …
[HTML][HTML] The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking
Neuroimmune interactions play a significant role in regulating synaptic plasticity in both the
healthy and diseased brain. The complement pathway, an extracellular proteolytic cascade …
healthy and diseased brain. The complement pathway, an extracellular proteolytic cascade …
[HTML][HTML] Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders
W Song, Q Li, T Wang, Y Li, T Fan, J Zhang… - Brain, Behavior, and …, 2022 - Elsevier
Recent studies have reported that complement-related proteins modulate brain
development through regulating synapse processes in the cortex. CSMD3 belongs to a …
development through regulating synapse processes in the cortex. CSMD3 belongs to a …
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice
Abstract The complement component 4 (C4) gene is linked to schizophrenia and synaptic
refinement. In humans, greater expression of C4A in the brain is associated with an …
refinement. In humans, greater expression of C4A in the brain is associated with an …
[HTML][HTML] Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations
EA Werren, ER Peirent, H Jantti, A Guxholli… - Cell Death & …, 2024 - nature.com
Abstract CSMD1 (Cub and Sushi Multiple Domains 1) is a well-recognized regulator of the
complement cascade, an important component of the innate immune response. CSMD1 is …
complement cascade, an important component of the innate immune response. CSMD1 is …