[HTML][HTML] Association of the MTHFR A1298C Variant with Unexplained Severe Male Infertility

A Eloualid, O Abidi, M Charif, B El Houate… - PloS one, 2012 - journals.plos.org
The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory
enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. The …

Relationship between genetic polymorphisms of methylenetetra hydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility

MR Safarinejad, N Shafiei… - Reproductive …, 2011 - journals.sagepub.com
Objective: The human methylenetetrahydrofolate reductase (MTHFR) gene plays a crucial
role in folate metabolism. Data regarding the influence of MTHFR gene polymorphisms on …

Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility

M Karimian, AH Colagar - Reproduction, Fertility and …, 2016 - CSIRO Publishing
The human methylenetetrahydrofolate reductase (MTHFR) gene encodes one of the key
enzymes in folate metabolism. This gene is located on chromosome 1 (1p36. 3), which has …

Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis

X Zhu, Z Liu, M Zhang, R Gong, Y Xu, B Wang - Renal failure, 2016 - Taylor & Francis
Several molecular epidemiological studies have been conducted to examine the association
between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and male …

Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta‐analysis

W Wu, O Shen, Y Qin, J Lu, X Niu… - … journal of andrology, 2012 - Wiley Online Library
Several molecular epidemiological studies have been conducted to examine the association
between MTHFR C677T polymorphism and male infertility susceptibility, but the results …

Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population

DS Mfady, MF Sadiq, OF Khabour, AFS Fararjeh… - Gene, 2014 - Elsevier
Folate pathway is expected to play an important role in spermatogenesis since it is involved
in DNA synthesis, repair and methylation. The purpose of this study was to examine the …

[PDF][PDF] Prospective study of MTHFR genetic polymorphisms as a possible etiology of male infertility

SS Li, J Li, Z Xiao, AG Ren, L Jin - Genet Mol Res, 2014 - funpecrp.com.br
The aim of this study was to explore the relationship between 2 genetic polymorphisms of
the methylenetetrahydrofolate reductase gene (MTHFR), C677T and A1298C, and …

[HTML][HTML] MTHFR A1298C polymorphism and idiopathic male infertility

K Singh, SK Singh, R Raman - Journal of Postgraduate Medicine, 2010 - journals.lww.com
Background: DNA methylation is an important epigenetic feature of DNA that plays a pivotal
role in gene expression regulation during spermatogenesis. The enzyme …

[HTML][HTML] Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk

N Gupta, S Sarkar, A David, PK Gangwar, R Gupta… - PloS one, 2013 - journals.plos.org
Background Methylenetetrahydrofolate reductase (MTHFR) converts 5, 10-methylene
tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles …

MTHFR C677T polymorphism associates with unexplained infertile male factors

JH Park, HC Lee, YM Jeong, TG Chung, HJ Kim… - Journal of Assisted …, 2005 - Springer
Abstract Purpose: To determine whether 5, 10-methylenetetrahydrofolate reductase (MTHFR
C677T and A1298C) genotype is associated with male infertility. Methods: Analysis of …