Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells
Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
T Chen, Y Ueda, JE Dodge, Z Wang… - Molecular and cellular …, 2003 - Am Soc Microbiol
We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …
de novo methylation of the mouse genome during early postimplantation development and …
Dnmt2-dependent methylomes lack defined DNA methylation patterns
G Raddatz, PM Guzzardo, N Olova… - Proceedings of the …, 2013 - National Acad Sciences
Several organisms have retained methyltransferase 2 (Dnmt2) as their only candidate DNA
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …
methyltransferase gene. However, information about Dnmt2-dependent methylation patterns …
Genome-wide DNA methylation signatures are determined by DNMT3A/B sequence preferences
Cytosine methylation is an important epigenetic mark, but how the distinctive patterns of
DNA methylation arise remains elusive. For the first time, we systematically investigated how …
DNA methylation arise remains elusive. For the first time, we systematically investigated how …
Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse
G Auclair, S Guibert, A Bender, M Weber - Genome biology, 2014 - Springer
Background In the mouse, the patterns of DNA methylation are established during early
embryonic development in the epiblast. We quantified the targets and kinetics of DNA …
embryonic development in the epiblast. We quantified the targets and kinetics of DNA …
[HTML][HTML] Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs
F Neri, A Krepelova, D Incarnato, M Maldotti, C Parlato… - Cell, 2013 - cell.com
The de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA
methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is …
methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is …
Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity
T Dahlet, A Argüeso Lleida, H Al Adhami… - Nature …, 2020 - nature.com
Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …
CpG sites preferentially methylated by Dnmt3a in vivo
M Oka, N Rodić, J Graddy, LJ Chang… - Journal of Biological …, 2006 - ASBMB
Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have …
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have …
DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible
gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for …
gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for …
DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
N Veland, Y Lu, S Hardikar, S Gaddis… - Nucleic acids …, 2019 - academic.oup.com
Abstract DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA
methyltransferase activity but regulates de novo DNA methylation. While biochemical …
methyltransferase activity but regulates de novo DNA methylation. While biochemical …